KCNN2 Antibody - #DF13499
(1)
(5)
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13499, RRID:AB_2846518.
免疫原
- Q9H2S1 KCNN2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
PTMs - Q9H2S1 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y6 | Phosphorylation | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| S18 | Phosphorylation | Uniprot | |
| T90 | Phosphorylation | Uniprot | |
| Y119 | Phosphorylation | Uniprot | |
| S135 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| K293 | Ubiquitination | Uniprot | |
| K401 | Ubiquitination | Uniprot | |
| S464 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| K466 | Sumoylation | Uniprot | |
| K484 | Acetylation | Uniprot | |
| T516 | Phosphorylation | Uniprot | |
| T531 | Phosphorylation | Uniprot | |
| S562 | Phosphorylation | Uniprot | |
| R566 | Methylation | Uniprot | |
| S567 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S568 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S569 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| T574 | Phosphorylation | Uniprot |
研究背景
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
Membrane>Multi-pass membrane protein.
Expressed in atrial myocytes (at protein level). Widely expressed.
Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).
Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.
研究領域
· Organismal Systems > Nervous system > Serotonergic synapse.
· Organismal Systems > Endocrine system > Insulin secretion. (View pathway)
参考文献
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.