CLCA1 Antibody - #DF13501
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13501, RRID:AB_2846520.
折りたたみ／展開
CaCC; CaCC-1; CACC1; Calcium dependent chloride channel 1; Calcium-activated chloride channel family member 1; Calcium-activated chloride channel protein 1; Calcium-activated chloride channel regulator 1; Chloride channel calcium activated family member 1; Chloride channel regulator 1; CLCA family member 1 chloride channel regulator; CLCA1; CLCA1_HUMAN; CLCRG1; GOB5; hCaCC-1; hCLCA1;
免疫原
Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.
- A8K7I4 CLCA1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGPFKSSVFILILHLLEGALSNSLIQLNNNGYEGIVVAIDPNVPEDETLIQQIKDMVTQASLYLLEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNADVLVAESTPPGNDEPYTEQMGNCGEKGERIHLTPDFIAGKKLAEYGPQGRAFVHEWAHLRWGVFDEYNNDEKFYLSNGRIQAVRCSAGITGTNVVKKCQGGSCYTKRCTFNKVTGLYEKGCEFVLQSRQTEKASIMFAQHVDSIVEFCTEQNHNKEAPNKQNQKCNLRSTWEVIRDSEDFKKTTPMTTQPPNPTFSLLQIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFLLQTVELGSWVGMVTFDSAAHVQNELIQINSGSDRDTLAKRLPAAASGGTSICSGLRSAFTVIRKKYPTDGSEIVLLTDGEDNTISGCFNEVKQSGAIIHTVALGPSAAQELEELSKMTGGLQTYASDQVQNNGLIDAFGALSSGNGAVSQRSIQLESKGLTLQNSQWMNGTVIVDSTVGKDTLFLITWTMQPPQILLWDPSGQKQGGFVVDKNTKMAYLQIPGIAKVGTWKYSLQASSQTLTLTVTSRASNATLPPITVTSKTNKDTSKFPSPLVVYANIRQGASPILRASVTALIESVNGKTVTLELLDNGAGADATKDDGVYSRYFTTYDTNGRYSVKVRALGGVNAARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDDVQHKQVCFSRTSSGGSFVASDVPNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAPGDDYDHGTAHKYIIRISTSILDLRDKFNESLQVNTTALIPKEANSEEVFLFKPENITFENGTDLFIAIQAVDKVDLKSEISNIARVSLFIPPQTPPETPSPDETSAPCPNIHINSTIPGIHILKIMWKWIGELQLSIA
PTMs - A8K7I4 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y91 | Phosphorylation | Uniprot | |
| Y99 | Phosphorylation | Uniprot | |
| Y147 | Phosphorylation | Uniprot | |
| C187 | S-Nitrosylation | Uniprot | |
| K208 | Acetylation | Uniprot | |
| T216 | Phosphorylation | Uniprot | |
| Y219 | Phosphorylation | Uniprot | |
| C308 | S-Nitrosylation | Uniprot | |
| S571 | Phosphorylation | Uniprot | |
| S572 | Phosphorylation | Uniprot | |
| T578 | Phosphorylation | Uniprot | |
| T580 | Phosphorylation | Uniprot | |
| Y661 | Phosphorylation | Uniprot | |
| Y665 | Phosphorylation | Uniprot | |
| Y671 | Phosphorylation | Uniprot |
研究背景
May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
Glycosylated.
The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37- to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.
Secreted>Extracellular space. Cell membrane>Peripheral membrane protein>Extracellular side.
Note: Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.
The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA substrates.
Belongs to the CLCR family.
研究領域
· Organismal Systems > Endocrine system > Renin secretion.
· Organismal Systems > Digestive system > Pancreatic secretion.
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