DAGLA Antibody - #DF13509
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13509, RRID:AB_2846528.
折りたたみ／展開
C11orf11; Chromosome 11 open reading frame 11; DAGL(ALPHA); Dagla; DAGLALPHA; DGL alpha; DGL-alpha; DGLA_HUMAN; Diacylglycerol lipase alpha; KIAA0659; Neural stem cell derived dendrite regulator; Neural stem cell-derived dendrite regulator; NSDDR; Sn1-specific diacylglycerol lipase alpha;
免疫原
- Q9Y4D2 DGLA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGRGYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLTQYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTYNLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGLVLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSQEMLRYKEVCYYMLFALAAYGWPMYLMRKPACGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLDENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVEGHHGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAILSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQLLDVLQRSTKPKWRIIVGATKCIPKSELPEEVEVTTLASTRLWTHPSDLTIALSASTPLYPPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLNKVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPMPTGLALELPTADHRNSSVRSKSQSEMSLEGFSEGRLLSPVVAAAARQDPVELLLLSTQERLAAELQARRAPLATMESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRTELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSAAANDEEEEVGGGGGGPASRGELALHNGRLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMVVPESPTSDYAEGPKSPSQQEILLRAQFEPNLVPKPPRLFAGSADPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLAADKIRTSTPTGHGASPAKQDELVISAR
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9Y4D2 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S396 | Phosphorylation | Uniprot | |
| T400 | Phosphorylation | Uniprot | |
| T411 | Phosphorylation | Uniprot | |
| T560 | Phosphorylation | Uniprot | |
| S566 | Phosphorylation | Uniprot | |
| K668 | Ubiquitination | Uniprot | |
| K670 | Ubiquitination | Uniprot | |
| S725 | Phosphorylation | Uniprot | |
| S727 | Phosphorylation | Uniprot | |
| S729 | Phosphorylation | Uniprot | |
| S732 | Phosphorylation | Uniprot | |
| S743 | Phosphorylation | Uniprot | |
| S782 | Phosphorylation | Q9UQM7 (CAMK2A) | Uniprot |
| S806 | Phosphorylation | Uniprot | |
| S808 | Phosphorylation | Q9UQM7 (CAMK2A) | Uniprot |
| S845 | Phosphorylation | Uniprot | |
| T866 | Phosphorylation | Uniprot | |
| S952 | Phosphorylation | Uniprot | |
| T1023 | Phosphorylation | Uniprot | |
| S1030 | Phosphorylation | Uniprot |
研究背景
Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
Cell membrane>Multi-pass membrane protein.
Highly expressed in brain and pancreas.
Belongs to the AB hydrolase superfamily. Lipase family.
研究領域
· Organismal Systems > Nervous system > Retrograde endocannabinoid signaling. (View pathway)
· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.
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