KMT2A / MLL Antibody - #DF13551

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製品: KMT2A / MLL Antibody
カタログ: DF13551
タンパク質の説明: Rabbit polyclonal antibody to KMT2A / MLL
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Horse, Dog, Chicken
分子量: 431kDa; 432kD(Calculated).
ユニプロット: Q03164
RRID: AB_2846570

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(88%), Bovine(88%), Horse(100%), Dog(100%), Chicken(88%)
クローナリティ:
Polyclonal
特異性:
KMT2A / MLL Antibody detects endogenous levels of total KMT2A / MLL.
RRID:
AB_2846570
引用形式: Affinity Biosciences Cat# DF13551, RRID:AB_2846570.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

ALL-1; ALL1; C-terminal cleavage product of 180 kDa; CXXC-type zinc finger protein 7; CXXC7; HRX; HTRX1; KMT2A; Lysine N-methyltransferase 2A; Mll; MLL cleavage product C180; MLL1; MLL1_HUMAN; MLL1A; N-terminal cleavage product of 320 kDa; p180; p320; Trithorax-like protein; TRX1; Zinc finger protein HRX;

免疫原

免疫原:
Uniprot:

Q03164(KMT2A_HUMAN) >>Visit HPA database.

遺伝子(ID):
KMT2A(4297)
発現特異性:
Q03164 KMT2A_HUMAN:

Heart, lung, brain and T- and B-lymphocytes.

タンパク質配列:
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPRSGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDSLKKIKRTPSATFQQATKIKKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRIIPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSRFSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGSRTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSNRTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESAEKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQSSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLCLSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALGRKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSEPPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPRPSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Dog
100
Pig
88
Bovine
88
Chicken
88
Sheep
0
Xenopus
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q03164 基板として

Site PTM Type Enzyme
T15 Phosphorylation
T16 Phosphorylation
R25 Methylation
R32 Methylation
S92 Phosphorylation
S93 Phosphorylation
S94 Phosphorylation
S95 Phosphorylation
S136 Phosphorylation
S142 Phosphorylation
S153 Phosphorylation
S161 Phosphorylation
T163 Phosphorylation
S165 Phosphorylation
S167 Phosphorylation
T170 Phosphorylation
S171 Phosphorylation
S181 Phosphorylation
S183 Phosphorylation
S187 Phosphorylation
S191 Phosphorylation
S194 Phosphorylation
S197 Phosphorylation
S202 Phosphorylation
T204 Phosphorylation
S206 Phosphorylation
K216 Ubiquitination
K220 Ubiquitination
K221 Ubiquitination
T259 Phosphorylation
S261 Phosphorylation
K277 Ubiquitination
S279 Phosphorylation
S283 Phosphorylation
K289 Ubiquitination
S308 Phosphorylation
T314 Phosphorylation
T337 Phosphorylation
S351 Phosphorylation
S363 Phosphorylation
S364 Phosphorylation
T424 Phosphorylation
K439 Ubiquitination
T446 Phosphorylation
S458 Phosphorylation
S459 Phosphorylation
S470 Phosphorylation
S504 Phosphorylation
T506 Phosphorylation
S516 Phosphorylation Q13535 (ATR)
S518 Phosphorylation
Y531 Phosphorylation
S532 Phosphorylation
S534 Phosphorylation
S537 Phosphorylation
S540 Phosphorylation
S610 Phosphorylation
K623 Methylation
S627 Phosphorylation
Y631 Phosphorylation
K636 Acetylation
K636 Methylation
K645 Ubiquitination
T657 Phosphorylation
S665 Phosphorylation
S668 Phosphorylation
S670 Phosphorylation
S680 Phosphorylation
S684 Phosphorylation
S694 Phosphorylation
R701 Methylation
T703 Phosphorylation
S705 Phosphorylation
T716 Phosphorylation
R721 Methylation
T722 Phosphorylation
S723 Phosphorylation
T726 Phosphorylation
S728 Phosphorylation
S742 Phosphorylation
S746 Phosphorylation
S750 Phosphorylation
S752 Phosphorylation
S754 Phosphorylation
T771 Phosphorylation
S828 Phosphorylation
S829 Phosphorylation
S831 Phosphorylation
T833 Phosphorylation
T840 Phosphorylation
S843 Phosphorylation
K895 Acetylation
S897 Phosphorylation
S912 Phosphorylation
S926 Phosphorylation
K928 Acetylation
T972 Phosphorylation
T979 Phosphorylation
S982 Phosphorylation
K985 Ubiquitination
S992 Phosphorylation
T993 Phosphorylation
S995 Phosphorylation
S1004 Phosphorylation
S1025 Phosphorylation
S1056 Phosphorylation
S1058 Phosphorylation
S1059 Phosphorylation
S1062 Phosphorylation
S1114 Phosphorylation
S1119 Phosphorylation
K1130 Acetylation
S1220 Phosphorylation
K1235 Acetylation
S1240 Phosphorylation
S1241 Phosphorylation
T1245 Phosphorylation
S1277 Phosphorylation
S1299 Phosphorylation
K1345 Acetylation
K1346 Acetylation
S1352 Phosphorylation
K1517 Ubiquitination
S1535 Phosphorylation
T1540 Phosphorylation
Y1576 Phosphorylation
Y1581 Phosphorylation
S1583 Phosphorylation
T1649 Phosphorylation
S1684 Phosphorylation
S1685 Phosphorylation
K1712 Ubiquitination
S1837 Phosphorylation
T1839 Phosphorylation
T1845 Phosphorylation
S1854 Phosphorylation
S1858 Phosphorylation
K1970 Ubiquitination
S2005 Phosphorylation
S2098 Phosphorylation
T2100 Phosphorylation
T2103 Phosphorylation
S2118 Phosphorylation
S2121 Phosphorylation
T2147 Phosphorylation
S2149 Phosphorylation
Y2150 Phosphorylation
S2151 Phosphorylation
T2153 Phosphorylation
S2156 Phosphorylation
S2164 Phosphorylation
S2167 Phosphorylation
T2169 Phosphorylation
T2171 Phosphorylation
S2185 Phosphorylation
S2196 Phosphorylation
T2197 Phosphorylation
S2198 Phosphorylation
S2199 Phosphorylation
S2201 Phosphorylation
S2211 Phosphorylation
S2291 Phosphorylation
S2298 Phosphorylation
S2301 Phosphorylation
S2302 Phosphorylation
S2313 Phosphorylation
S2315 Phosphorylation
S2316 Phosphorylation
S2350 Phosphorylation
S2391 Phosphorylation
S2392 Phosphorylation
S2420 Phosphorylation
S2493 Phosphorylation
S2508 Phosphorylation
T2523 Phosphorylation
T2525 Phosphorylation
S2611 Phosphorylation
Y2616 Phosphorylation
S2625 Phosphorylation
T2632 Phosphorylation
Y2635 Phosphorylation
T2652 Phosphorylation
K2654 Acetylation
K2655 Acetylation
S2691 Phosphorylation
T2724 Phosphorylation
S2726 Phosphorylation
T2728 Phosphorylation
T2731 Phosphorylation
T2733 Phosphorylation
T2734 Phosphorylation
K2746 Acetylation
T2750 Phosphorylation
K2754 Acetylation
K2775 Acetylation
K2790 Ubiquitination
T2791 Phosphorylation
S2796 Phosphorylation
T2814 Phosphorylation
K2818 Acetylation
S2866 Phosphorylation
S2872 Phosphorylation
S2885 Phosphorylation
S2909 Phosphorylation
S2938 Phosphorylation
T2940 Phosphorylation
S2955 Phosphorylation
K2958 Acetylation
S3026 Phosphorylation
S3027 Phosphorylation
T3028 Phosphorylation
S3036 Phosphorylation
T3038 Phosphorylation
S3050 Phosphorylation
S3053 Phosphorylation
S3057 Phosphorylation
T3067 Phosphorylation
S3208 Phosphorylation
T3210 Phosphorylation
T3213 Phosphorylation
S3216 Phosphorylation
K3219 Acetylation
T3281 Phosphorylation
K3287 Ubiquitination
T3372 Phosphorylation
S3502 Phosphorylation
S3508 Phosphorylation
T3510 Phosphorylation
S3511 Phosphorylation
S3515 Phosphorylation
S3517 Phosphorylation
S3518 Phosphorylation
S3520 Phosphorylation
S3521 Phosphorylation
S3525 Phosphorylation
S3527 Phosphorylation
K3535 Acetylation
K3549 Acetylation
K3553 Acetylation
T3634 Phosphorylation
S3643 Phosphorylation
S3644 Phosphorylation
K3696 Ubiquitination
K3707 Ubiquitination
K3749 Acetylation
K3749 Ubiquitination
K3784 Ubiquitination
K3804 Methylation
K3804 Ubiquitination
S3827 Phosphorylation
S3836 Phosphorylation
Y3914 Phosphorylation
K3945 Ubiquitination
K3954 Ubiquitination

研究背景

機能:

Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity).

PTMs:

Proteolytic cleavage by TASP1 generates MLL cleavage product N320 and MLL cleavage product C180, which reassemble through a non-covalent association. 2 cleavage sites exist, cleavage site 1 (CS1) and cleavage site 2 (CS2), to generate MLL cleavage products N320 and C180. CS2 is the major site.

Phosphorylation increases its interaction with PSIP1.

細胞の位置付け:

Nucleus.

Nucleus.

Nucleus.
Note: Localizes to a diffuse nuclear pattern when not associated with MLL cleavage product N320.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Heart, lung, brain and T- and B-lymphocytes.

サブユニット構造:

MLL cleavage product N320 heterodimerizes with MLL cleavage product C180 (via SET and FYRC domains). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, HCFC2, WDR5, DPY30 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts (via WIN motif) with WDR5; the interaction is direct. Interaction with WDR5 is required for stable interaction with ASH2L and RBBP5, and thereby also for optimal histone methyltransferase activity. Interacts with KAT8/MOF; the interaction is direct. Interacts with SBF1 and PPP1R15A. Interacts with ZNF335. Interacts with CLOCK and ARNTL/BMAL1 in a circadian manner (By similarity). Interacts with PPIE; this results in decreased histone H3 methyltransferase activity. Interacts with CREBBP. Interacts with the WRAD complex composed of WDR5, RBBP5, ASH2L and DPY30. Interacts (via MBM motif) with MEN1. Interacts (via IBM motifs) with PSIP1 (via IBD domain) with moderate affinity whereas the KMT2A-MEN1 complex interacts with a greater affinity; MEN1 enhances interaction of KMT2A with PSIP1. Phosphorylation increases its affinity for PSIP1. Forms a complex with CREBBP and CREB1.

タンパク質ファミリー:

The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

The SET domain structure is atypical and is not in an optimal position to have methyltransferase activity. It requires other components of the MLL1/MLL complex, such as ASH2L or RBBP5, to order the active site and obtain optimal histone methyltransferase activity.

The CXXC-type zinc finger binds to DNA sequence elements containing unnmethylated CpG dinucleotides.

The third PHD-type zinc-finger binds both trimethylated histone H3K4me3 and PPIE; histone and PPIE bind to distinct surfaces (PubMed:20677832, PubMed:20541251). Nevertheless, PPIE binding and histone binding are mutually inhibitory (PubMed:20677832). Isomerization of a peptidylproline bond in the linker between the third PHD-type zinc-finger and the bromo domain disrupts the interaction between the bromo domain and the third PHD-type zinc-finger, and thereby facilitates interaction with PPIE (PubMed:20541251).

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.

研究領域

· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.

· Metabolism > Amino acid metabolism > Lysine degradation.

参考文献

1). A novel lncRNA SNHG29 regulates EP300- related histone acetylation modification and inhibits FLT3-ITD AML development. Leukemia, 2023 (PubMed: 37157016) [IF=11.4]

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