Kinesin 5 C Antibody - #DF13556
| 製品: | Kinesin 5 C Antibody |
| カタログ: | DF13556 |
| タンパク質の説明: | Rabbit polyclonal antibody to Kinesin 5 C |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 109kDa; 109kD(Calculated). |
| ユニプロット: | O60282 |
| RRID: | AB_2846575 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13556, RRID:AB_2846575.
折りたたみ／展開
CDCBM2; FLJ44735; KIAA0531; KIF 5C; Kif5c; KIF5C protein; KIF5C_HUMAN; Kinesin family member 5C; Kinesin heavy chain isoform 5C; Kinesin heavy chain neuron specific 2; Kinesin heavy chain neuron specific; Kinesin heavy chain neuron-specific 2; Kinesin5C; KINN; MGC111478; NKHC 2; NKHC; NKHC-2; NKHC2;
免疫原
Highest expression in brain, prostate and testis, and moderate expression in kidney, small intestine and ovary.
- O60282 KIF5C_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MADPAECSIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVIGQGKPYVFDRVLPPNTTQEQVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGEAVPEDEQISAKDQKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEEISSLYRQLDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHREAHQKQLSRLRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIEDQEREMKLEKLLLLNDKREQAREDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQEVDRIKEAVRAKNMARRAHSAQIAKPIRPGHYPASSPTAVHAIRGGGGSSSNSTHYQK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O60282 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K167 | Acetylation | Uniprot | |
| S176 | Phosphorylation | P53779 (MAPK10) | Uniprot |
| K227 | Ubiquitination | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| K274 | Ubiquitination | Uniprot | |
| S316 | Phosphorylation | Uniprot | |
| T317 | Phosphorylation | Uniprot | |
| T326 | Phosphorylation | Uniprot | |
| K348 | Acetylation | Uniprot | |
| K501 | Ubiquitination | Uniprot | |
| Y590 | Phosphorylation | Uniprot | |
| S596 | Phosphorylation | Uniprot | |
| S610 | Phosphorylation | Uniprot | |
| S615 | Phosphorylation | Uniprot | |
| S660 | Phosphorylation | Uniprot | |
| R692 | Methylation | Uniprot | |
| R711 | Methylation | Uniprot | |
| Y753 | Phosphorylation | Uniprot | |
| K814 | Acetylation | Uniprot | |
| S816 | Phosphorylation | Uniprot | |
| S835 | Phosphorylation | Uniprot | |
| K846 | Ubiquitination | Uniprot | |
| K849 | Ubiquitination | Uniprot | |
| R903 | Methylation | Uniprot | |
| S919 | Phosphorylation | Uniprot | |
| S934 | Phosphorylation | Uniprot | |
| S935 | Phosphorylation | Uniprot |
研究背景
Involved in synaptic transmission. Mediates dendritic trafficking of mRNAs (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity).
Cytoplasm>Cytoskeleton. Cell projection>Dendrite.
Note: Abundant in distal regions of dendrites.
Highest expression in brain, prostate and testis, and moderate expression in kidney, small intestine and ovary.
Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and KLC3 (By similarity). Interacts with TRAK1. Interacts with ZFYVE27 (By similarity).
Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Organismal Systems > Nervous system > Dopaminergic synapse.
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