SLC40A1 Antibody - #DF13561

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製品: SLC40A1 Antibody
カタログ: DF13561
タンパク質の説明: Rabbit polyclonal antibody to SLC40A1
アプリケーション: WB IHC
Cited expt.: WB, IHC
反応性: Human, Mouse, Rat
予測: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Chicken, Xenopus
分子量: 62kDa; 63kD(Calculated).
ユニプロット: Q9NP59
RRID: AB_2846580

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(100%), Zebrafish(88%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Chicken(100%), Xenopus(100%)
クローナリティ:
Polyclonal
特異性:
SLC40A1 Antibody detects endogenous levels of total SLC40A1.
RRID:
AB_2846580
引用形式: Affinity Biosciences Cat# DF13561, RRID:AB_2846580.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Ferroportin 1; Ferroportin; Ferroportin-1; FPN1; HFE4; IREG1; iron regulated gene 1; Iron regulated transporter 1; Iron-regulated transporter 1; MST079; MSTP079; MTP1; putative ferroportin 1 variant IIIA; putative ferroportin 1 variant IIIB; S40A1_HUMAN; SLC11A3; SLC11A3, formerly; SLC40A1; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3, formerly; solute carrier family 40 (iron-regulated transporter), member 1; Solute carrier family 40 member 1;

免疫原

免疫原:

A synthesized peptide derived from human SLC40A1, corresponding to a region within N-terminal amino acids.

Uniprot:

Q9NP59(S40A1_HUMAN) >>Visit HPA database.

遺伝子(ID):
SLC40A1(30061)
発現特異性:
Q9NP59 S40A1_HUMAN:

Detected in erythrocytes (at protein level). Expressed in placenta, intestine, muscle and spleen.

タンパク質配列:
MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHELLTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLKEEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITPTKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFRFAQNTLGNKLFACGPDAKEVRKENQANTSVV

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Xenopus
100
Chicken
100
Rabbit
100
Zebrafish
88
Dog
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).

細胞の位置付け:

Cell membrane>Multi-pass membrane protein.
Note: Localized to the basolateral membrane of polarized epithelial cells.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Detected in erythrocytes (at protein level). Expressed in placenta, intestine, muscle and spleen.

タンパク質ファミリー:

Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.

研究領域

· Cellular Processes > Cell growth and death > Ferroptosis.   (View pathway)

· Organismal Systems > Digestive system > Mineral absorption.

参考文献

1). Modified Fish-Skin-Collagen-Based Hydrogels with Antioxidant and Antibacterial Functions for Diabetic Wound Healing. Advanced Healthcare Materials, 2025 [IF=9.6]
2). Bone morphogenetic protein 4 derived from the cerebrospinal fluid in patients with postherpetic neuralgia induces allodynia via the crosstalk between microglia and astrocyte. Brain, behavior, and immunity, 2024 (PubMed: 38735405) [IF=8.8]
3). Voluntary exercise alleviates neural functional deficits in Parkinson's disease mice by inhibiting microglial ferroptosis via SLC7A11/ALOX12 axis. NPJ Parkinson's disease, 2025 (PubMed: 40122927) [IF=8.7]
4). Defective ferritinophagy and imbalanced iron metabolism in PBDE-47-triggered neuronal ferroptosis and salvage by Canolol. The Science of the total environment, 2024 (PubMed: 38750757) [IF=8.2]
5). Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury. Free radical biology & medicine, 2023 (PubMed: 36805045) [IF=7.1]
6). GSK-3β-dependent Nrf2 antioxidant response modulates ferroptosis of lens epithelial cells in age-related cataract. Free Radical Biology and Medicine, 2023 (PubMed: 37156294) [IF=7.1]
7). Biochanin A protects against iron overload associated knee osteoarthritis via regulating iron levels and NRF2/System xc-/GPX4 axis. Biomedicine & Pharmacotherapy, 2023 (PubMed: 36379122) [IF=6.9]
8). Protective benefits of salvianic acid A against retinal iron overload by inhibition of ferroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023 (PubMed: 37429233) [IF=6.9]
9). Dihydroartemisinin inhibits galectin-1-induced ferroptosis resistance and peritoneal metastasis of gastric cancer via the Nrf2-HO-1 pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2025 (PubMed: 41166905) [IF=6.7]

Application: IHC    Species: human    Sample: GC tissues

Fig. 8. Clinical significance of Nrf2/HO-1/GPX4 expression in GC. An analysis of the GEPIA database revealed the expression levels of NFE2L2 (A), HMOX1 (B), and GPX4 (C) in GC tissues compared with normal tissues, along with their prognostic significance for GC patients. (D) The correlation analysis between HMOX1 and NFE2L2 expression and between HMOX1 and GPX4 expression in GC tissues was performed using the GEPIA database. (E–H) Western blot analysis of Nrf2, HO-1, and GPX4 expression in GC tissues and adjacent noncancer tissues. (I, J) Immunofluorescence staining was performed to analyse the expression of Nrf2, HO-1, and GPX4 in GC tissues from patients with or without PM (400 × magnification), followed by relative fluorescence quantification. (K) GC tissues obtained from patients with or without PM were processed for H&E staining, iron staining, and IHC for TfR1 and FPN1 (400 × magnification). (L) The IODs of iron staining and the IRSs of TfR1 and FPN1 in each group were compared.
10). Moderate static magnetic field regulates iron metabolism and salvage bone loss caused by iron accumulation. Journal of orthopaedic translation, 2025 (PubMed: 40171108) [IF=5.9]
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