KCC2 Antibody - #DF13580
| 製品: | KCC2 Antibody |
| カタログ: | DF13580 |
| タンパク質の説明: | Rabbit polyclonal antibody to KCC2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 126kDa; 126kD(Calculated). |
| ユニプロット: | Q9H2X9 |
| RRID: | AB_2846599 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13580, RRID:AB_2846599.
折りたたみ／展開
Electroneutral potassium chloride cotransporter 2; Electroneutral potassium-chloride cotransporter 2; Erythroid K Cl cotransporter 2; Furosemide sensitive K Cl cotransporter; hKCC2; K-Cl cotransporter 2; KCC 2; KCC2; KIAA1176; Neuronal K Cl cotransporter; Neuronal K-Cl cotransporter; Potassium Chloride Cotransporter; Potassium chloride transporter 5; rKCC2; S12A5; S12A5_HUMAN; SLC12A5; Solute carrier family 12 (potassium chloride transporter) member 5; Solute carrier family 12 member 5;
免疫原
- Q9H2X9 S12A5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSRRFTVTSLPPAGPARSPDPESRRHSVADPRHLPGEDVKGDGNPKESSPFINSTDTEKGKEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEGETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS
PTMs - Q9H2X9 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| T6 | Phosphorylation | Q9UEW8 (STK39) | Uniprot |
| S27 | Phosphorylation | Uniprot | |
| S54 | Phosphorylation | Uniprot | |
| T57 | Phosphorylation | Uniprot | |
| T77 | Phosphorylation | Uniprot | |
| S78 | Phosphorylation | Uniprot | |
| S82 | Phosphorylation | Uniprot | |
| T92 | Phosphorylation | Uniprot | |
| T501 | Phosphorylation | Uniprot | |
| Y617 | Phosphorylation | Uniprot | |
| S622 | Phosphorylation | Uniprot | |
| T821 | Phosphorylation | Uniprot | |
| T831 | Phosphorylation | Uniprot | |
| T929 | Phosphorylation | Uniprot | |
| S963 | Phosphorylation | Uniprot | |
| T1030 | Phosphorylation | Uniprot | |
| T1032 | Phosphorylation | Q9UEW8 (STK39) | Uniprot |
| Y1110 | Phosphorylation | Uniprot |
研究背景
Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation.
Membrane>Multi-pass membrane protein.
Brain specific. Detected in neuronal cells.
Homomultimer and heteromultimer with other K-Cl cotransporters. Interacts with AP2A1 (By similarity).
Belongs to the SLC12A transporter family.
研究領域
· Organismal Systems > Nervous system > GABAergic synapse.
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