PRDM2 Antibody - #DF13607
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13607, RRID:AB_2846626.
折りたたみ／展開
GATA 3 binding protein G3B; GATA-3-binding protein G3B; HUMHOXY1; Lysine N methyltransferase 8; Lysine N-methyltransferase 8; MTB ZF; MTB-ZF; MTE binding protein; MTE-binding protein; PR domain containing 2 with ZNF domain; PR domain containing protein 2; PR domain zinc finger protein 2; PR domain-containing protein 2; PRDM2; PRDM2_HUMAN; Retinoblastoma protein binding zinc finger protein; Retinoblastoma protein interacting zinc- inger protein; Retinoblastoma protein-interacting zinc finger protein; RIZ; RIZ-LSB; RIZ1; RIZ2; Zinc finger DNA binding protein; Zinc finger protein RIZ;
免疫原
Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3.
- Q13029 PRDM2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGKKKSQENKNKGNKIQDIQLKTSEPDFTSANMRDSAEGPKEDEEKPSASALEQPATLQEVASQEVPPELATPAPAWEPQPEPDERLEAAACEVNDLGEEEEEEEEEDEEEEEDDDDDELEDEGEEEASMPNENSVKEPEIRCDEKPEDLLEEPKTTSEETLEDCSEVTPAMQIPRTKEEANGDVFETFMFPCQHCERKFTTKQGLERHMHIHISTVNHAFKCKYCGKAFGTQINRRRHERRHEAGLKRKPSQTLQPSEDLADGKASGENVASKDDSSPPSLGPDCLIMNSEKASQDTINSSVVEENGEVKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLEEPQPPAEQAQATQNVYVPSTEPEEEGEADDVYIMDISSNISENLNYYIDGKIQTNNNTSNCDVIEMESASADLYGINCLLTPVTVEITQNIKTTQVPVTEDLPKEPLGSTNSEAKKRRTASPPALPKIKAETDSDPMVPSCSLSLPLSISTTEAVSFHKEKSVYLSSKLKQLLQTQDKLTPAGISATEIAKLGPVCVSAPASMLPVTSSRFKRRTSSPPSSPQHSPALRDFGKPSDGKAAWTDAGLTSKKSKLESHSDSPAWSLSGRDERETVSPPCFDEYKMSKEWTASSAFSSVCNQQPLDLSSGVKQKAEGTGKTPVQWESVLDLSVHKKHCSDSEGKEFKESHSVQPTCSAVKKRKPTTCMLQKVLLNEYNGIDLPVENPADGTRSPSPCKSLEAQPDPDLGPGSGFPAPTVESTPDVCPSSPALQTPSLSSGQLPPLLIPTDPSSPPPCPPVLTVATPPPPLLPTVPLPAPSSSASPHPCPSPLSNATAQSPLPILSPTVSPSPSPIPPVEPLMSAASPGPPTLSSSSSSSSSSSSFSSSSSSSSPSPPPLSAISSVVSSGDNLEASLPMISFKQEELENEGLKPREEPQSAAEQDVVVQETFNKNFVCNVCESPFLSIKDLTKHLSIHAEEWPFKCEFCVQLFKDKTDLSEHRFLLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDKVCTHHEFESGTLRPQNFTDPSKAHVEHMQSLPEDPLETSKEEEELNDSSEELYTTIKIMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRNPMGIGVTATNFTTHNIPQTFTTAIRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSGKNAFRRMGQPKRLNFSVELSKMSSNKLKLNALKKKNQLVQKAILQKNKSAKQKADLKNACESSSHICPYCNREFTYIGSLNKHAAFSCPKKPLSPPKKKVSHSSKKGGHSSPASSDKNSNSNHRRRTADAEIKMQSMQTPLGKTRARSSGPTQVPLPSSSFRSKQNVKFAASVKSKKPSSSSLRNSSPIRMAKITHVEGKKPKAVAKNHSAQLSSKTSRSLHVRVQKSKAVLQSKSTLASKKRTDRFNIKSRERSGGPVTRSLQLAAAADLSENKREDGSAKQELKDFSYSLRLASRCSPPAAPYITRQYRKVKAPAAAQFQGPFFKE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13029 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T47 | Phosphorylation | Uniprot | |
| K63 | Ubiquitination | Uniprot | |
| T198 | Phosphorylation | Uniprot | |
| S199 | Phosphorylation | Uniprot | |
| S421 | Phosphorylation | Uniprot | |
| T423 | Phosphorylation | Uniprot | |
| S427 | Phosphorylation | Uniprot | |
| S447 | Phosphorylation | Uniprot | |
| S471 | Phosphorylation | Uniprot | |
| R508 | Methylation | Uniprot | |
| R516 | Methylation | Uniprot | |
| K626 | Ubiquitination | Uniprot | |
| T641 | Phosphorylation | Uniprot | |
| S643 | Phosphorylation | Uniprot | |
| K700 | Ubiquitination | Uniprot | |
| T702 | Phosphorylation | Uniprot | |
| S720 | Phosphorylation | Uniprot | |
| T737 | Phosphorylation | Uniprot | |
| S738 | Phosphorylation | Uniprot | |
| S739 | Phosphorylation | Uniprot | |
| S742 | Phosphorylation | Uniprot | |
| S743 | Phosphorylation | Uniprot | |
| S747 | Phosphorylation | Uniprot | |
| K774 | Ubiquitination | Uniprot | |
| S781 | Phosphorylation | Uniprot | |
| S785 | Phosphorylation | Uniprot | |
| S796 | Phosphorylation | Uniprot | |
| S846 | Phosphorylation | Uniprot | |
| S876 | Phosphorylation | Uniprot | |
| T885 | Phosphorylation | Uniprot | |
| Y896 | Phosphorylation | Uniprot | |
| T910 | Phosphorylation | Uniprot | |
| S912 | Phosphorylation | Uniprot | |
| S914 | Phosphorylation | Uniprot | |
| S1054 | Phosphorylation | Uniprot | |
| S1055 | Phosphorylation | Uniprot | |
| S1056 | Phosphorylation | Uniprot | |
| S1057 | Phosphorylation | Uniprot | |
| S1118 | Phosphorylation | Uniprot | |
| S1141 | Phosphorylation | Uniprot | |
| T1255 | Phosphorylation | Uniprot | |
| S1256 | Phosphorylation | Uniprot | |
| S1265 | Phosphorylation | Uniprot | |
| S1266 | Phosphorylation | Uniprot | |
| Y1295 | Phosphorylation | Uniprot | |
| S1297 | Phosphorylation | Uniprot | |
| S1359 | Phosphorylation | Uniprot | |
| S1414 | Phosphorylation | Uniprot | |
| K1425 | Acetylation | Uniprot | |
| K1431 | Acetylation | Uniprot | |
| S1484 | Phosphorylation | Uniprot | |
| S1491 | Phosphorylation | Uniprot | |
| S1509 | Phosphorylation | Uniprot | |
| S1511 | Phosphorylation | Uniprot | |
| T1529 | Phosphorylation | Uniprot | |
| S1571 | Phosphorylation | Uniprot | |
| T1585 | Phosphorylation | Uniprot | |
| K1597 | Ubiquitination | Uniprot | |
| K1606 | Ubiquitination | Uniprot | |
| S1641 | Phosphorylation | Uniprot | |
| S1645 | Phosphorylation | Uniprot | |
| S1652 | Phosphorylation | Uniprot |
研究背景
S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.
Nucleus.
Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3.
Binds to the retinoblastoma protein (RB). Interacts with GATA3.
Belongs to the class V-like SAM-binding methyltransferase superfamily.
研究領域
· Metabolism > Amino acid metabolism > Lysine degradation.
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