Hhip Antibody - #DF13634
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(13)
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13634, RRID:AB_2846653.
折りたたみ／展開
FLJ20992; FLJ90230; Hedgehog interacting protein; Hedgehog-interacting protein; hedgehoginteracting protein; HHIP; HHIP_HUMAN; Hip;
免疫原
Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney.
- Q96QV1 HHIP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLKMLSFKLLLLAVALGFFEGDAKFGERNEGSGARRRRCLNGNPPKRLKRRDRRMMSQLELLSGGEMLCGGFYPRLSCCLRSDSPGLGRLENKIFSVTNNTECGKLLEEIKCALCSPHSQSLFHSPEREVLERDLVLPLLCKDYCKEFFYTCRGHIPGFLQTTADEFCFYYARKDGGLCFPDFPRKQVRGPASNYLDQMEEYDKVEEISRKHKHNCFCIQEVVSGLRQPVGALHSGDGSQRLFILEKEGYVKILTPEGEIFKEPYLDIHKLVQSGIKGGDERGLLSLAFHPNYKKNGKLYVSYTTNQERWAIGPHDHILRVVEYTVSRKNPHQVDLRTARVFLEVAELHRKHLGGQLLFGPDGFLYIILGDGMITLDDMEEMDGLSDFTGSVLRLDVDTDMCNVPYSIPRSNPHFNSTNQPPEVFAHGLHDPGRCAVDRHPTDININLTILCSDSNGKNRSSARILQIIKGKDYESEPSLLEFKPFSNGPLVGGFVYRGCQSERLYGSYVFGDRNGNFLTLQQSPVTKQWQEKPLCLGTSGSCRGYFSGHILGFGEDELGEVYILSSSKSMTQTHNGKLYKIVDPKRPLMPEECRATVQPAQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQVDRNIRRVTRAGILDQIIDMTSYLLDLTSYIV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96QV1 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K93 | Ubiquitination | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| K174 | Ubiquitination | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| K262 | Ubiquitination | Uniprot | |
| K270 | Ubiquitination | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| Y293 | Phosphorylation | Uniprot | |
| K329 | Ubiquitination | Uniprot | |
| N447 | N-Glycosylation | Uniprot | |
| K472 | Ubiquitination | Uniprot | |
| K533 | Ubiquitination | Uniprot | |
| Y616 | Phosphorylation | Uniprot | |
| T618 | Phosphorylation | Uniprot | |
| T620 | Phosphorylation | Uniprot | |
| K622 | Ubiquitination | Uniprot | |
| S626 | Phosphorylation | Uniprot | |
| K659 | Ubiquitination | Uniprot |
研究背景
Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.
Cell membrane>Peripheral membrane protein. Secreted.
Note: The last 22 C-terminal amino acids may participate in cell membrane attachment.
Cytoplasm.
Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney.
Interacts with all three hedgehog family members, SHH, IHH and DHH.
A flexible loop interacts with the SHH zinc binding site and contributes to zinc binding.
Belongs to the HHIP family.
研究領域
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Hedgehog signaling pathway. (View pathway)
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Basal cell carcinoma. (View pathway)
参考文献
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