Glycogen synthase 2 Antibody - #DF13655
| 製品: | Glycogen synthase 2 Antibody |
| カタログ: | DF13655 |
| タンパク質の説明: | Rabbit polyclonal antibody to Glycogen synthase 2 |
| アプリケーション: | WB |
| 反応性: | Human |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 80kDa; 81kD(Calculated). |
| ユニプロット: | P54840 |
| RRID: | AB_2846674 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13655, RRID:AB_2846674.
折りたたみ／展開
EC 2.4.1.11; Glycogen [starch] synthase; Glycogen starch synthase liver; Glycogen synthase 2 liver; Gys2; GYS2_HUMAN; liver;
免疫原
- P54840 GYS2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P54840 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Phosphorylation | Uniprot | ||
| S6 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Q13131 (PRKAA1) | Uniprot |
| T10 | Phosphorylation | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| Y45 | Phosphorylation | Uniprot | |
| T46 | Phosphorylation | Uniprot | |
| T50 | Phosphorylation | Uniprot | |
| T203 | Phosphorylation | Uniprot | |
| K371 | Acetylation | Uniprot | |
| K381 | Ubiquitination | Uniprot | |
| K387 | Acetylation | Uniprot | |
| K397 | Acetylation | Uniprot | |
| Y405 | Phosphorylation | Uniprot | |
| T426 | Phosphorylation | Uniprot | |
| S627 | Phosphorylation | Uniprot | |
| S683 | Phosphorylation | Uniprot | |
| S686 | Phosphorylation | Uniprot | |
| S688 | Phosphorylation | Uniprot |
研究背景
Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme (By similarity). Phosphorylation at Ser-8 is not required for interaction with GYG1 (By similarity). Interaction with GYG1 does not regulate the phosphorylation at Ser-8 and Ser-641 (By similarity).
Interacts with GYG1 (via C-terminus); required for GYS2-mediated glycogen synthesis.
Belongs to the glycosyltransferase 3 family.
研究領域
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > AMPK signaling pathway. (View pathway)
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
· Metabolism > Carbohydrate metabolism > Starch and sucrose metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Endocrine system > Insulin signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Glucagon signaling pathway.
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