UBR4 Antibody - #DF13659
(15)
製品説明
ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
反応性:
Human,Mouse,Rat
予測:
Pig(100%), Bovine(100%), Sheep(100%), Rabbit(100%), Dog(100%)
クローナリティ:
Polyclonal
特異性:
UBR4 Antibody detects endogenous levels of total UBR4.
RRID:
AB_2846678
引用形式: Affinity Biosciences Cat# DF13659, RRID:AB_2846678.
引用形式: Affinity Biosciences Cat# DF13659, RRID:AB_2846678.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:
折りたたみ／展開
600 kDa retinoblastoma protein associated factor; 600 kDa retinoblastoma protein-associated factor; E3 ubiquitin-protein ligase UBR4; KIAA0462; KIAA1307; N-recognin-4; p600; RBAF600; Retinoblastoma associated factor 600 like protein; Retinoblastoma associated factor of 600 kDa; Retinoblastoma-associated factor 600; Retinoblastoma-associated factor of 600 kDa; Ubiquitin protein ligase E3 component n recognin 4; UBR4; UBR4_HUMAN; Zinc finger UBR1 type protein 1; Zinc finger UBR1-type protein 1; Zinc finger, UBR1 type 1; ZUBR 1; ZUBR1;
免疫原
免疫原:
Uniprot:
遺伝子(ID):
タンパク質配列:
- Q5T4S7 UBR4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSRTKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAALSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVKSPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHHMATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPFSEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGVVPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRFVPLILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRATTPLYHGFKEVEENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKLVKYDELYAALTALLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYINQLSMNSPEMSECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVEIVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAETDPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAAVLAIGSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSESYISAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLESSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILEECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQLLTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAGHLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNALSQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMKESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPKKSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQALSELHTVEKAVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQLMEEASSAQQGPFYVTNVLEINHEDLKDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKSFAATISRTTLEVLQLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGDSDSAAPTTTSGTVLERLVVSSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPASVQQQSKSLLASLHTSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAIMRPNNLVHFTESKLPQMETEGMDEGKEPQKQLEGDCCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPNGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLSGQAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQEGDGSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVATSQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKITDTNSRIPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSGSSSASSSSAPVAASSGQATTQSKSSTKKSKKEEKEKEKDGETSGSQEDQLCTALVNQLNKFADKETLIQFLRCFLLESNSSSVRWQAHCLTLHIYRNSSKSQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTPQTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQDDSGTAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAATKSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHILVSQGLIRELFDYNLRRGAAAMREEVRQLMCLLTRDNPEATQQMNDLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLWLKRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHLYLTEKYVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYLAARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTVLALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLDVAGLLSEITDPESFLKDLLNSVP
種類予測
種類予測:
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Zebrafish
75
Horse
0
Xenopus
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q5T4S7 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T18 | Phosphorylation | Uniprot | |
| S59 | Phosphorylation | Uniprot | |
| S61 | Phosphorylation | Uniprot | |
| S111 | Phosphorylation | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| K159 | Ubiquitination | Uniprot | |
| K165 | Ubiquitination | Uniprot | |
| K174 | Ubiquitination | Uniprot | |
| S178 | Phosphorylation | Uniprot | |
| S181 | Phosphorylation | Uniprot | |
| K187 | Ubiquitination | Uniprot | |
| K234 | Ubiquitination | Uniprot | |
| K236 | Ubiquitination | Uniprot | |
| K255 | Ubiquitination | Uniprot | |
| T360 | Phosphorylation | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| T363 | Phosphorylation | Uniprot | |
| S364 | Phosphorylation | Uniprot | |
| S365 | Phosphorylation | Uniprot | |
| K366 | Ubiquitination | Uniprot | |
| Y370 | Phosphorylation | Uniprot | |
| S372 | Phosphorylation | Uniprot | |
| T376 | Phosphorylation | Uniprot | |
| Y385 | Phosphorylation | Uniprot | |
| K436 | Ubiquitination | Uniprot | |
| S457 | Phosphorylation | Uniprot | |
| K459 | Ubiquitination | Uniprot | |
| T485 | Phosphorylation | Uniprot | |
| S486 | Phosphorylation | Uniprot | |
| S555 | Phosphorylation | Uniprot | |
| S557 | Phosphorylation | Uniprot | |
| K605 | Ubiquitination | Uniprot | |
| S619 | Phosphorylation | Uniprot | |
| S620 | Phosphorylation | Uniprot | |
| S625 | Phosphorylation | Uniprot | |
| S627 | Phosphorylation | Uniprot | |
| K634 | Ubiquitination | Uniprot | |
| S665 | Phosphorylation | Uniprot | |
| K781 | Ubiquitination | Uniprot | |
| T904 | Phosphorylation | Uniprot | |
| T905 | Phosphorylation | Uniprot | |
| K920 | Ubiquitination | Uniprot | |
| Y963 | Phosphorylation | Uniprot | |
| Y1001 | Phosphorylation | Uniprot | |
| Y1002 | Phosphorylation | Uniprot | |
| K1060 | Ubiquitination | Uniprot | |
| K1064 | Ubiquitination | Uniprot | |
| K1079 | Ubiquitination | Uniprot | |
| K1084 | Acetylation | Uniprot | |
| K1084 | Ubiquitination | Uniprot | |
| K1141 | Ubiquitination | Uniprot | |
| K1150 | Ubiquitination | Uniprot | |
| K1156 | Ubiquitination | Uniprot | |
| K1189 | Ubiquitination | Uniprot | |
| K1477 | Ubiquitination | Uniprot | |
| K1574 | Ubiquitination | Uniprot | |
| K1579 | Ubiquitination | Uniprot | |
| S1634 | Phosphorylation | Uniprot | |
| S1647 | Phosphorylation | Uniprot | |
| S1652 | Phosphorylation | Uniprot | |
| K1729 | Ubiquitination | Uniprot | |
| T1731 | Phosphorylation | Uniprot | |
| S1733 | Phosphorylation | Uniprot | |
| T1739 | Phosphorylation | Uniprot | |
| K1741 | Ubiquitination | Uniprot | |
| S1747 | Phosphorylation | Uniprot | |
| S1752 | Phosphorylation | Uniprot | |
| S1754 | Phosphorylation | Uniprot | |
| S1760 | Phosphorylation | Uniprot | |
| T1761 | Phosphorylation | Uniprot | |
| S1762 | Phosphorylation | Uniprot | |
| S1763 | Phosphorylation | Uniprot | |
| K1769 | Ubiquitination | Uniprot | |
| S1773 | Phosphorylation | Uniprot | |
| K1776 | Ubiquitination | Uniprot | |
| S1878 | Phosphorylation | Uniprot | |
| T1884 | Phosphorylation | Uniprot | |
| S1904 | Phosphorylation | Uniprot | |
| K1931 | Acetylation | Uniprot | |
| K1931 | Ubiquitination | Uniprot | |
| K1939 | Ubiquitination | Uniprot | |
| T1941 | Phosphorylation | Uniprot | |
| T1943 | Phosphorylation | Uniprot | |
| S1947 | Phosphorylation | Uniprot | |
| T1958 | Phosphorylation | Uniprot | |
| Y2087 | Phosphorylation | Uniprot | |
| S2131 | Phosphorylation | Uniprot | |
| T2140 | Phosphorylation | Uniprot | |
| T2196 | Phosphorylation | Uniprot | |
| T2204 | Phosphorylation | Uniprot | |
| K2210 | Ubiquitination | Uniprot | |
| R2227 | Methylation | Uniprot | |
| Y2242 | Phosphorylation | Uniprot | |
| K2273 | Ubiquitination | Uniprot | |
| K2502 | Ubiquitination | Uniprot | |
| Y2539 | Phosphorylation | Uniprot | |
| S2541 | Phosphorylation | Uniprot | |
| K2543 | Ubiquitination | Uniprot | |
| S2549 | Phosphorylation | Uniprot | |
| K2550 | Ubiquitination | Uniprot | |
| K2560 | Ubiquitination | Uniprot | |
| K2563 | Ubiquitination | Uniprot | |
| K2698 | Ubiquitination | Uniprot | |
| T2715 | Phosphorylation | Uniprot | |
| S2718 | Phosphorylation | Uniprot | |
| S2719 | Phosphorylation | Uniprot | |
| S2722 | Phosphorylation | Uniprot | |
| T2724 | Phosphorylation | Uniprot | |
| S2743 | Phosphorylation | Uniprot | |
| S2756 | Phosphorylation | Uniprot | |
| T2884 | Phosphorylation | Uniprot | |
| S2885 | Phosphorylation | Uniprot | |
| S2892 | Phosphorylation | Uniprot | |
| S2895 | Phosphorylation | Uniprot | |
| S2897 | Phosphorylation | Uniprot | |
| S2900 | Phosphorylation | Uniprot | |
| S2910 | Phosphorylation | Uniprot | |
| Y2918 | Phosphorylation | Uniprot | |
| S2932 | Phosphorylation | P42345 (MTOR) | Uniprot |
| S2934 | Phosphorylation | Uniprot | |
| T2937 | Phosphorylation | Uniprot | |
| T2942 | Phosphorylation | Uniprot | |
| T2943 | Phosphorylation | Uniprot | |
| T2944 | Phosphorylation | Uniprot | |
| S2952 | Phosphorylation | Uniprot | |
| T2960 | Phosphorylation | Uniprot | |
| K3126 | Ubiquitination | Uniprot | |
| S3132 | Phosphorylation | Uniprot | |
| Y3169 | Phosphorylation | Uniprot | |
| T3175 | Phosphorylation | Uniprot | |
| T3177 | Phosphorylation | Uniprot | |
| S3179 | Phosphorylation | Uniprot | |
| S3220 | Phosphorylation | Uniprot | |
| K3292 | Ubiquitination | Uniprot | |
| S3339 | Phosphorylation | Uniprot | |
| S3346 | Phosphorylation | Uniprot | |
| S3347 | Phosphorylation | Uniprot | |
| S3349 | Phosphorylation | Uniprot | |
| T3361 | Phosphorylation | Uniprot | |
| S3366 | Phosphorylation | Uniprot | |
| T3367 | Phosphorylation | Uniprot | |
| K3379 | Ubiquitination | Uniprot | |
| S3386 | Phosphorylation | Uniprot | |
| K3401 | Ubiquitination | Uniprot | |
| K3405 | Ubiquitination | Uniprot | |
| K3464 | Ubiquitination | Uniprot | |
| K3485 | Ubiquitination | Uniprot | |
| K3487 | Ubiquitination | Uniprot | |
| K3551 | Ubiquitination | Uniprot | |
| K3573 | Ubiquitination | Uniprot | |
| K3577 | Ubiquitination | Uniprot | |
| K3617 | Ubiquitination | Uniprot | |
| K3745 | Ubiquitination | Uniprot | |
| K3774 | Ubiquitination | Uniprot | |
| K3808 | Ubiquitination | Uniprot | |
| K3816 | Ubiquitination | Uniprot | |
| K3820 | Ubiquitination | Uniprot | |
| K3826 | Ubiquitination | Uniprot | |
| S3842 | Phosphorylation | Uniprot | |
| S3854 | Phosphorylation | Uniprot | |
| S3860 | Phosphorylation | Uniprot | |
| T3892 | Phosphorylation | Uniprot | |
| T4005 | Phosphorylation | Uniprot | |
| T4013 | Phosphorylation | Uniprot | |
| K4035 | Ubiquitination | Uniprot | |
| K4065 | Ubiquitination | Uniprot | |
| Y4068 | Phosphorylation | Uniprot | |
| K4072 | Ubiquitination | Uniprot | |
| R4078 | Methylation | Uniprot | |
| K4089 | Ubiquitination | Uniprot | |
| K4100 | Ubiquitination | Uniprot | |
| K4106 | Ubiquitination | Uniprot | |
| S4117 | Phosphorylation | Uniprot | |
| K4122 | Ubiquitination | Uniprot | |
| R4158 | Methylation | Uniprot | |
| K4215 | Ubiquitination | Uniprot | |
| T4300 | Phosphorylation | Uniprot | |
| T4316 | Phosphorylation | Uniprot | |
| Y4325 | Phosphorylation | Uniprot | |
| S4416 | Phosphorylation | Uniprot | |
| K4427 | Ubiquitination | Uniprot | |
| R4491 | Methylation | Uniprot | |
| R4496 | Methylation | Uniprot | |
| K4685 | Ubiquitination | Uniprot | |
| K4696 | Ubiquitination | Uniprot | |
| K4703 | Ubiquitination | Uniprot | |
| K4711 | Ubiquitination | Uniprot | |
| K4712 | Ubiquitination | Uniprot | |
| S4755 | Phosphorylation | Uniprot | |
| T4762 | Phosphorylation | Uniprot | |
| K4802 | Ubiquitination | Uniprot | |
| K4814 | Ubiquitination | Uniprot | |
| T4819 | Phosphorylation | Uniprot | |
| K4820 | Ubiquitination | Uniprot | |
| K4860 | Ubiquitination | Uniprot | |
| S4973 | Phosphorylation | Uniprot | |
| S4975 | Phosphorylation | Uniprot | |
| T4978 | Phosphorylation | Uniprot | |
| K5022 | Ubiquitination | Uniprot | |
| Y5135 | Phosphorylation | Uniprot |
研究背景
機能:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
細胞の位置付け:
Membrane>Multi-pass membrane protein. Cytoplasm. Cytoplasm>Cytoskeleton. Nucleus.
Note: Concentrates at the leading edge of membrane structures involved in actin motility.
サブユニット構造:
Interacts with RB1 and calmodulin.
(Microbial infection) Interacts with protein E7 from papilloma virus HPV-16, HPV-6B and HPV-11.
タンパク質ファミリー:
Belongs to the UBR4 family.
研究領域
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Human Diseases > Cancers: Overview > Viral carcinogenesis.
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