HB EGF Antibody - #DF13666
| 製品: | HB EGF Antibody |
| カタログ: | DF13666 |
| タンパク質の説明: | Rabbit polyclonal antibody to HB EGF |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Horse, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 23kDa; 23kD(Calculated). |
| ユニプロット: | Q99075 |
| RRID: | AB_2846685 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13666, RRID:AB_2846685.
折りたたみ／展開
diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); Diphtheria toxin receptor; DT R; DT-R; DTR; DTS; DTSF; HB-EGF; HBEGF; HBEGF_HUMAN; HEGFL; Heparin binding EGF like growth factor; Heparin binding epidermal growth factor; Heparin binding epidermal growth factor like growth factor; Heparin-binding EGF-like growth factor; Proheparin binding EGF like growth factor;
免疫原
- Q99075 HBEGF_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAGTSNPDPPTVSTDQLLPLGGGRDRKVRDLQEADLDLLRVTLSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDVENEEKVKLGMTNSH
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q99075 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| T37 | O-Glycosylation | Uniprot | |
| T37 | Phosphorylation | Uniprot | |
| S38 | O-Glycosylation | Uniprot | |
| S38 | Phosphorylation | Uniprot | |
| T44 | O-Glycosylation | Uniprot | |
| T44 | Phosphorylation | Uniprot | |
| T47 | O-Glycosylation | Uniprot | |
| T75 | O-Glycosylation | Uniprot | |
| S77 | O-Glycosylation | Uniprot | |
| S78 | O-Glycosylation | Uniprot | |
| T85 | O-Glycosylation | Uniprot | |
| K95 | Acetylation | Uniprot | |
| K96 | Acetylation | Uniprot | |
| K97 | Acetylation | Uniprot | |
| K99 | Acetylation | Uniprot | |
| K103 | Acetylation | Uniprot | |
| K104 | Acetylation | Uniprot | |
| S207 | Phosphorylation | Uniprot |
研究背景
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.
O-glycosylated with core 1 or possibly core 8 glycans. Thr-47 is a minor glycosylation site compared to Thr-44.
Secreted>Extracellular space.
Note: Mature HB-EGF is released into the extracellular space and probably binds to a receptor.
Cell membrane>Single-pass type I membrane protein.
Interacts with FBLN1 (By similarity). Interacts with EGFR and ERBB4.
研究領域
· Environmental Information Processing > Signal transduction > ErbB signaling pathway. (View pathway)
· Human Diseases > Drug resistance: Antineoplastic > Endocrine resistance.
· Human Diseases > Infectious diseases: Bacterial > Epithelial cell signaling in Helicobacter pylori infection.
· Human Diseases > Cancers: Overview > Proteoglycans in cancer.
· Human Diseases > Cancers: Specific types > Bladder cancer. (View pathway)
· Organismal Systems > Endocrine system > Estrogen signaling pathway. (View pathway)
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.