AADACL1 Antibody - #DF13688
| 製品: | AADACL1 Antibody |
| カタログ: | DF13688 |
| タンパク質の説明: | Rabbit polyclonal antibody to AADACL1 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 45kDa; 46kD(Calculated). |
| ユニプロット: | Q6PIU2 |
| RRID: | AB_2846707 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13688, RRID:AB_2846707.
折りたたみ／展開
Arylacetamide deacetylase like 1; Arylacetamide deacetylase-like 1; NCEH; Nceh1; NCEH1_HUMAN; Neutral cholesterol ester hydrolase 1; Neutral cholesterol ester hydrolase;
免疫原
Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines.
- Q6PIU2 NCEH1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRSSCVLLTALVALAAYYVYIPLPGSVSDPWKLMLLDATFRGAQQVSNLIHYLGLSHHLLALNFIIVSFGKKSAWSSAQVKVTDTDFDGVEVRVFEGPPKPEEPLKRSVVYIHGGGWALASAKIRYYDELCTAMAEELNAVIVSIEYRLVPKVYFPEQIHDVVRATKYFLKPEVLQKYMVDPGRICISGDSAGGNLAAALGQQFTQDASLKNKLKLQALIYPVLQALDFNTPSYQQNVNTPILPRYVMVKYWVDYFKGNYDFVQAMIVNNHTSLDVEEAAAVRARLNWTSLLPASFTKNYKPVVQTTGNARIVQELPQLLDARSAPLIADQAVLQLLPKTYILTCEHDVLRDDGIMYAKRLESAGVEVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSYIKWLDQNL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q6PIU2 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T85 | Phosphorylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| S144 | Phosphorylation | Uniprot | |
| Y168 | Phosphorylation | Uniprot | |
| T240 | Phosphorylation | Uniprot | |
| N287 | N-Glycosylation | Uniprot | |
| S295 | Phosphorylation | Uniprot | |
| T297 | Phosphorylation | Uniprot | |
| K301 | Ubiquitination | Uniprot |
研究背景
Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration.
N-glycosylated.
Membrane>Single-pass type II membrane protein. Microsome.
Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines.
Belongs to the 'GDXG' lipolytic enzyme family.
研究領域
· Organismal Systems > Digestive system > Cholesterol metabolism.
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