IL21 Receptor Antibody - #DF13734
| 製品: | IL21 Receptor Antibody |
| カタログ: | DF13734 |
| タンパク質の説明: | Rabbit polyclonal antibody to IL21 Receptor |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Pig |
| 分子量: | 59kDa; 59kD(Calculated). |
| ユニプロット: | Q9HBE5 |
| RRID: | AB_2846753 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13734, RRID:AB_2846753.
折りたたみ／展開
CD360; IL 21R; IL-21 receptor; IL-21R; IL21 receptor; IL21R; IL21R_HUMAN; Interleukin 21 receptor; Interleukin-21 receptor; MGC10967; NILR; Novel interleukin receptor;
免疫原
Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.
- Q9HBE5 IL21R_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEELKDEATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIKPAPPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKLISVDSRSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNPHLLLLLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSIDTVTVLDAEGPCTWPCSCEDDGYPALDLDAGLEPSPGLEDPLLDAGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGEDWAGGLPWGGRSPGGVSESEAGSPLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9HBE5 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N73 | N-Glycosylation | Uniprot | |
| R201 | Methylation | Uniprot | |
| W214 | C-Glycosylation | Uniprot |
研究背景
This is a receptor for interleukin-21.
C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.
Membrane>Single-pass type I membrane protein.
Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.
Heterodimer with the common gamma subunit. Associates with JAK1.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Belongs to the type I cytokine receptor family. Type 4 subfamily.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Human Diseases > Immune diseases > Inflammatory bowel disease (IBD).
· Organismal Systems > Immune system > Th17 cell differentiation. (View pathway)
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