MEKK1 Antibody - #AF0007
| 製品: | MEKK1 Antibody |
| カタログ: | AF0007 |
| タンパク質の説明: | Rabbit polyclonal antibody to MEKK1 |
| アプリケーション: | IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 161 kDa; 164kD(Calculated). |
| ユニプロット: | Q13233 |
| RRID: | AB_2846784 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF0007, RRID:AB_2846784.
折りたたみ／展開
M3K1_HUMAN; MAP3K1; MAPK/ERK kinase kinase 1; MAPKKK1; MEK kinase 1; MEKK 1; Mekk; MEKK1; Mitogen activated protein kinase kinase kinase 1; Mitogen activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Mitogen-activated protein kinase kinase kinase 1; SRXY6;
免疫原
A synthesized peptide derived from human MAP3K1.
- Q13233 M3K1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAAAGNRASSSGFPGARATSPEAGGGGGALKASSAPAAAAGLLREAGSGGRERADWRRRQLRKVRSVELDQLPEQPLFLAASPPASSTSPSPEPADAAGSGTGFQPVAVPPPHGAASRGGAHLTESVAAPDSGASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASAASPASKGRRSPSPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHTLSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFNLTHYGTQQIPPAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGSSGSSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEMLSVSSSTHFTRMRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENSSPECTVHLEKTGKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKGRPHSQCLNSSPLSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNSMTLDLNSSSKCDDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTTW
PTMs - Q13233 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| T20 | Phosphorylation | Uniprot | |
| S21 | Phosphorylation | Uniprot | |
| S35 | Phosphorylation | Uniprot | |
| S67 | Phosphorylation | P01116 (KRAS) , Q13153 (PAK1) | Uniprot |
| S133 | Phosphorylation | Uniprot | |
| S137 | Phosphorylation | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| S242 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| S252 | Phosphorylation | Uniprot | |
| T261 | Phosphorylation | Uniprot | |
| S264 | Phosphorylation | Uniprot | |
| S266 | Phosphorylation | Uniprot | |
| S275 | Phosphorylation | Uniprot | |
| S281 | Phosphorylation | Uniprot | |
| T285 | Phosphorylation | Uniprot | |
| S292 | Phosphorylation | Uniprot | |
| S297 | Phosphorylation | Uniprot | |
| S300 | Phosphorylation | Uniprot | |
| S333 | Phosphorylation | Uniprot | |
| K391 | Ubiquitination | Uniprot | |
| S431 | Phosphorylation | Uniprot | |
| K436 | Sumoylation | Uniprot | |
| S507 | Phosphorylation | Uniprot | |
| S511 | Phosphorylation | Uniprot | |
| T522 | Phosphorylation | Uniprot | |
| S531 | Phosphorylation | Uniprot | |
| T542 | Phosphorylation | Uniprot | |
| T657 | Phosphorylation | Uniprot | |
| T665 | Phosphorylation | Uniprot | |
| T686 | Phosphorylation | Uniprot | |
| K690 | Ubiquitination | Uniprot | |
| S796 | Phosphorylation | Uniprot | |
| S844 | Phosphorylation | Uniprot | |
| T850 | Phosphorylation | Uniprot | |
| K919 | Ubiquitination | Uniprot | |
| S921 | Phosphorylation | Uniprot | |
| S923 | Phosphorylation | Uniprot | |
| S928 | Phosphorylation | Uniprot | |
| S970 | Phosphorylation | Q13546 (RIPK1) | Uniprot |
| T999 | Phosphorylation | Uniprot | |
| S1016 | Phosphorylation | Uniprot | |
| S1018 | Phosphorylation | Uniprot | |
| S1026 | Phosphorylation | Uniprot | |
| S1043 | Phosphorylation | Uniprot | |
| T1082 | Phosphorylation | Uniprot | |
| S1087 | Phosphorylation | Uniprot | |
| S1089 | Phosphorylation | Uniprot | |
| T1114 | Phosphorylation | Uniprot | |
| S1157 | Phosphorylation | Uniprot | |
| K1168 | Ubiquitination | Uniprot | |
| K1176 | Ubiquitination | Uniprot | |
| Y1338 | Phosphorylation | Uniprot | |
| K1371 | Ubiquitination | Uniprot | |
| K1398 | Ubiquitination | Uniprot | |
| Y1400 | Phosphorylation | Uniprot | |
| Y1412 | Phosphorylation | Uniprot | |
| S1455 | Phosphorylation | Uniprot |
PTMs - Q13233 酵素として
| Substrate | Site | Source |
|---|---|---|
| O14733 (MAP2K7) | S271 | Uniprot |
| O14733 (MAP2K7) | T275 | Uniprot |
| P40763 (STAT3) | S727 | Uniprot |
| P45985 (MAP2K4) | T261 | Uniprot |
| P52564 (MAP2K6) | T211 | Uniprot |
| Q02750 (MAP2K1) | S218 | Uniprot |
| Q02750 (MAP2K1) | S222 | Uniprot |
| Q13158 (FADD) | S194 | Uniprot |
| Q8NHW3 (MAFA) | S14 | Uniprot |
| Q8NHW3 (MAFA) | S65 | Uniprot |
研究背景
Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.
Autophosphorylated.
Binds both upstream activators and downstream substrates in multimolecular complexes through its N-terminus. Oligomerizes after binding MAP2K4 or TRAF2. Interacts with AXIN1. Interacts (via the kinase catalytic domain) with STK38. Interacts with GRIPAP1.
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
· Genetic Information Processing > Folding, sorting and degradation > Ubiquitin mediated proteolysis. (View pathway)
· Human Diseases > Infectious diseases: Viral > Hepatitis B.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Organismal Systems > Immune system > RIG-I-like receptor signaling pathway. (View pathway)
· Organismal Systems > Nervous system > Neurotrophin signaling pathway. (View pathway)
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