BCL9L Antibody - #AF2622
| 製品: | BCL9L Antibody |
| カタログ: | AF2622 |
| タンパク質の説明: | Rabbit polyclonal antibody to BCL9L |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 200kDa; 157kD(Calculated). |
| ユニプロット: | Q86UU0 |
| RRID: | AB_2846802 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF2622, RRID:AB_2846802.
折りたたみ／展開
B-cell CLL; B-cell CLL/lymphoma 9-like protein; B-cell lymphoma 9-like protein; B9L; BCL9-2; BCL9-like protein; BCL9-related beta-catenin-binding protein; Bcl9l; BCL9L_HUMAN; DLNB11; Nuclear co factor of beta catenin signalling; Protein BCL9-2;
免疫原
A synthesized peptide derived from human BCL9L.
Expressed in breast, ductal and invasive ductal carcinomas of the breast, sporadic colorectal adenomas and carcinomas (at protein level). Expressed in fetal brain. Expressed in lung, amygdala, eye, prostate, pancreatic and prostate cancers, head and neck tumors and embryonal tumor.
- Q86UU0 BCL9L_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRILANKTRLPHPRRREAPGSPPLSPRGHCPPAPAKPMHPENKLTNHGKTGNGGAQSQHQNVNQGPTCNVGSKGVGAGNHGAKANQISPSNSSLKNPQAGVPPFSSLKGKVKRDRSVSVDSGEQREAGTPSLDSEAKEVAPRSKRRCVLERKQPYSGDEWCSGPDSEEDDKPIGATHNCNVADPAMAAPQLGPGQTTQLPLSESSVPGAPHGPPPGLRPDAPGGGGGGGGVPGKPPSQFVYVFTTHLANTAAEAVLQGRADSILAYHQQNVPRAKLDQAPKVPPTPEPLPLSTPSAGTPQSQPPPLPPPPPPAPGSAPPALPPEGPPEDSSQDLAPNSVGAASTGGGTGGTHPNTPTATTANNPLPPGGDPSSAPGPALLGEAAAPGNGQRSLVGSEGLSKEQLEHRERSLQTLRDIERLLLRSGETEPFLKGPPGGAGEGGPPAQAPPPPQQPPTAPPSGLKKYEEPLQSMISQTQSLGGPPLEHEVPGHPPGGDMGQQMNMMIQRLGQDSLTPEQVAWRKLQEEYYEEKRRKEEQIGLHGSRPLQDMMGMGGMMVRGPPPPYHSKPGDQWPPGMGAQLRGPMDVQDPMQLRGGPPFPGPRFPGNQIQRVPGFGGMQSMPMEVPMNAMQRPVRPGMGWTEDLPPMGGPSNFAQNTMPYPGGQGEAERFMTPRVREELLRHQLLEKRSMGMQRPLGMAGSGMGQSMEMERMMQAHRQMDPAMFPGQMAGGEGLAGTPMGMEFGGGRGLLSPPMGQSGLREVDPPMGPGNLNMNMNVNMNMNMNLNVQMTPQQQMLMSQKMRGPGDLMGPQGLSPEEMARVRAQNSSGVMGGPQKMLMPSQFPNQGQQGFSGGQGPYQAMSQDMGNTQDMFSPDQSSMPMSNVGTTRLSHMPLPPASNPPGTVHSAPNRGLGRRPSDLTISINQMGSPGMGHLKSPTLSQVHSPLVTSPSANLKSPQTPSQMVPLPSANPPGPLKSPQVLGSSLSVRSPTGSPSRLKSPSMAVPSPGWVASPKTAMPSPGVSQNKQPPLNMNSSTTLSNMEQGTLPPSGPRSSSSAPPANPPSGLMNPSLPFTSSPDPTPSQNPLSLMMTQMSKYAMPSSTPLYHNAIKTIATSDDELLPDRPLLPPPPPPQGSGPGISNSQPSQMHLNSAAAQSPMGMNLPGQQPLSHEPPPAMLPSPTPLGSNIPLHPNAQGTGGPPQNSMMMAPGGPDSLNAPCGPVPSSSQMMPFPPRLQQPHGAMAPTGGGGGGPGLQQHYPSGMALPPEDLPNQPPGPMPPQQHLMGKAMAGRMGDAYPPGVLPGVASVLNDPELSEVIRPTPTGIPEFDLSRIIPSEKPSSTLQYFPKSENQPPKAQPPNLHLMNLQNMMAEQTPSRPPNLPGQQGVQRGLNMSMCHPGQMSLLGRTGVPPQQGMVPHGLHQGVMSPPQGLMTQQNFMLMKQRGVGGEVYSQPPHMLSPQGSLMGPPPQQNLMVSHPLRQRSVSLDSQMGYLPAPGGMANLPF
PTMs - Q86UU0 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S21 | Phosphorylation | Uniprot | |
| S25 | Phosphorylation | Uniprot | |
| K36 | Acetylation | Uniprot | |
| K43 | Acetylation | Uniprot | |
| K49 | Acetylation | Uniprot | |
| C68 | S-Nitrosylation | Uniprot | |
| K73 | Acetylation | Uniprot | |
| K83 | Acetylation | Uniprot | |
| S88 | Phosphorylation | Uniprot | |
| S93 | Phosphorylation | Uniprot | |
| S105 | Phosphorylation | Uniprot | |
| S106 | Phosphorylation | Uniprot | |
| K108 | Acetylation | Uniprot | |
| K110 | Acetylation | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| S121 | Phosphorylation | Uniprot | |
| T129 | Phosphorylation | Uniprot | |
| K137 | Acetylation | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| K401 | Ubiquitination | Uniprot | |
| S410 | Phosphorylation | Uniprot | |
| S424 | Phosphorylation | Uniprot | |
| Y465 | Phosphorylation | Uniprot | |
| T514 | Phosphorylation | Uniprot | |
| K522 | Sumoylation | Uniprot | |
| Y527 | Phosphorylation | Uniprot | |
| K531 | Ubiquitination | Uniprot | |
| K534 | Acetylation | Uniprot | |
| R593 | Methylation | Uniprot | |
| R602 | Methylation | Uniprot | |
| R610 | Methylation | Uniprot | |
| R668 | Methylation | Uniprot | |
| R675 | Methylation | Uniprot | |
| R680 | Methylation | Uniprot | |
| S750 | Phosphorylation | Uniprot | |
| S813 | Phosphorylation | Uniprot | |
| R821 | Methylation | Uniprot | |
| S915 | Phosphorylation | Uniprot | |
| T918 | Phosphorylation | Uniprot | |
| S926 | Phosphorylation | Uniprot | |
| S934 | Phosphorylation | Uniprot | |
| T936 | Phosphorylation | Uniprot | |
| S938 | Phosphorylation | Uniprot | |
| S942 | Phosphorylation | Uniprot | |
| T946 | Phosphorylation | Uniprot | |
| S947 | Phosphorylation | Uniprot | |
| S949 | Phosphorylation | Uniprot | |
| S954 | Phosphorylation | Uniprot | |
| T957 | Phosphorylation | Uniprot | |
| S959 | Phosphorylation | Uniprot | |
| S975 | Phosphorylation | Uniprot | |
| S987 | Phosphorylation | Uniprot | |
| T989 | Phosphorylation | Uniprot | |
| S991 | Phosphorylation | Uniprot | |
| S993 | Phosphorylation | Uniprot | |
| S997 | Phosphorylation | Uniprot | |
| S999 | Phosphorylation | Uniprot | |
| S1004 | Phosphorylation | Uniprot | |
| S1010 | Phosphorylation | Uniprot | |
| T1013 | Phosphorylation | Uniprot | |
| S1017 | Phosphorylation | Uniprot | |
| S1021 | Phosphorylation | Uniprot | |
| K1334 | Acetylation | Uniprot | |
| K1344 | Sumoylation | Uniprot | |
| R1439 | Methylation | Uniprot | |
| Y1446 | Phosphorylation | Uniprot | |
| S1447 | Phosphorylation | Uniprot | |
| S1454 | Phosphorylation | Uniprot | |
| S1458 | Phosphorylation | Uniprot | |
| S1478 | Phosphorylation | Uniprot | |
| S1480 | Phosphorylation | Uniprot |
研究背景
Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity).
Nucleus.
Expressed in breast, ductal and invasive ductal carcinomas of the breast, sporadic colorectal adenomas and carcinomas (at protein level). Expressed in fetal brain. Expressed in lung, amygdala, eye, prostate, pancreatic and prostate cancers, head and neck tumors and embryonal tumor.
Found in a complex with CDC73; CTNNB1 and PYGO1. Interacts with CTNNB1.
Tne C-terminal domain is important for its transactivation activity.
Belongs to the BCL9 family.
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