Phospho-SIRT6 (Thr294) Antibody - #AF3571
| 製品: | Phospho-SIRT6 (Thr294) Antibody |
| カタログ: | AF3571 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-SIRT6 (Thr294) |
| アプリケーション: | IF/ICC |
| 反応性: | Human |
| 分子量: | 39kD(Calculated). |
| ユニプロット: | Q8N6T7 |
| RRID: | AB_2846885 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF3571, RRID:AB_2846885.
折りたたみ／展開
2810449N18Rik; AI043036; Mono ADP ribosyltransferase sirtuin 6; NAD-dependent protein deacetylase sirtuin-6; Regulatory protein SIR2 homolog 6; Regulatory protein SIR2 homolog; SIR2 like 6; SIR2 like protein 6; Sir2 related protein type 6; SIR2-like protein 6; SIR2L6; SIR6_HUMAN; SIRT 6; SIRT6; Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); Sirtuin 6; Sirtuin type 6; Sirtuin6;
免疫原
A synthesized peptide derived from human SIRT6 around the phosphorylation site of Thr294.
- Q8N6T7 SIR6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
PTMs - Q8N6T7 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| K17 | Ubiquitination | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| K128 | Ubiquitination | Uniprot | |
| T146 | Phosphorylation | Uniprot | |
| Y148 | Phosphorylation | Uniprot | |
| K160 | Ubiquitination | Uniprot | |
| T162 | Phosphorylation | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| K245 | Ubiquitination | Uniprot | |
| K267 | Ubiquitination | Uniprot | |
| T294 | Phosphorylation | Uniprot | |
| S303 | Phosphorylation | Uniprot | |
| T305 | Phosphorylation | Uniprot | |
| S310 | Phosphorylation | Uniprot | |
| S326 | Phosphorylation | Uniprot | |
| S330 | Phosphorylation | Uniprot | |
| T337 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | P31749 (AKT1) | Uniprot |
研究背景
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
Nucleus>Nucleoplasm.
Note: Predominantly nuclear. Associated with telomeric heterochromatin regions.
Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8.
Belongs to the sirtuin family. Class IV subfamily.
研究領域
· Human Diseases > Cancers: Overview > Central carbon metabolism in cancer. (View pathway)
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