Phospho-Histone H1 (Thr17) Antibody - #AF3572
| 製品: | Phospho-Histone H1 (Thr17) Antibody |
| カタログ: | AF3572 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-Histone H1 (Thr17) |
| アプリケーション: | ELISA(peptide) |
| 反応性: | Human |
| 分子量: | 36kD(Calculated). |
| ユニプロット: | Q8IZA3 |
| RRID: | AB_2846886 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF3572, RRID:AB_2846886.
折りたたみ／展開
H1 histone family member O oocyte specific; H1FOO; H1FOO_HUMAN; Histone H1oo; Oocyte-specific histone H1; Oocyte-specific linker histone H1; osH1;
免疫原
A synthesized peptide derived from human Histone H1 around the phosphorylation site of Thr17.
- Q8IZA3 H1FOO_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPGSVTSDISPSSTSTAGSSRSPESEKPGPSHGGVPPGGPSHSSLPVGRRHPPVLRMVLEALQAGEQRRGTSVAAIKLYILHKYPTVDVLRFKYLLKQALATGMRRGLLARPLNSKARGATGSFKLVPKHKKKIQPRKMAPATAPRRAGEAKGKGPKKPSEAKEDPPNVGKVKKAAKRPAKVQKPPPKPGAATEKARKQGGAAKDTRAQSGEARKVPPKPDKAMRAPSSAGGLSRKAKAKGSRSSQGDAEAYRKTKAESKSSKPTASKVKNGAASPTKKKVVAKAKAPKAGQGPNTKAAAPAKGSGSKVVPAHLSRKTEAPKGPRKAGLPIKASSSKVSSQRAEA
PTMs - Q8IZA3 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T7 | Phosphorylation | Uniprot | |
| S26 | Phosphorylation | Uniprot | |
| R147 | Methylation | Uniprot | |
| K153 | Acetylation | Uniprot | |
| K155 | Acetylation | Uniprot | |
| K158 | Acetylation | Uniprot | |
| K205 | Methylation | Uniprot | |
| S245 | Phosphorylation | Uniprot | |
| S246 | Phosphorylation | Uniprot | |
| Y253 | Phosphorylation | Uniprot |
研究背景
May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity).
Cytoplasm. Nucleus. Chromosome.
Oocyte-specific.
Belongs to the histone H1/H5 family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.