Phospho-PFKFB3 (Ser461) Antibody - #AF3581
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製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF3581, RRID:AB_2846895.
折りたたみ／展開
6 phosphofructo 2 kinase/ fructose 2,6 bisphosphatase; 6 phosphofructo 2 kinase/fructose 2,6 biphosphatase 3; 6-bisphosphatase; 6-P2ase 3; 6-P2ASE brain/placenta-type isozyme; 6PF 2 K/Fru 2,6 P2ASE brain/placenta type isozyme; 6PF 2-K/Fru 2,6 P2ase 3; 6PF-2-K/Fru-2; F263_HUMAN; fructose 6 phosphate,2 kinase/fructose 2, 6 bisphosphatase; Fructose-2; Inducible 6 phosphofructo 2 kinase/fructose 2,6 bisphosphatase; iPFK 2; iPFK-2; IPFK2; PFK/FBPase 3; PFK2; PFKFB3; Renal carcinoma antigen NY REN 56; Renal carcinoma antigen NY-REN-56; uPFK;
免疫原
A synthesized peptide derived from human PFKFB3 around the phosphorylation site of Ser461.
- Q16875 F263_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFEEHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKH
PTMs - Q16875 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K12 | Ubiquitination | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| K97 | Ubiquitination | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| K111 | Ubiquitination | Uniprot | |
| K116 | Ubiquitination | Uniprot | |
| S172 | Phosphorylation | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| Y194 | Phosphorylation | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| S269 | Phosphorylation | O14920 (IKBKB) | Uniprot |
| S273 | Phosphorylation | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| S283 | Phosphorylation | Uniprot | |
| K284 | Ubiquitination | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| K302 | Ubiquitination | Uniprot | |
| K319 | Ubiquitination | Uniprot | |
| K352 | Ubiquitination | Uniprot | |
| K411 | Ubiquitination | Uniprot | |
| S461 | Phosphorylation | Q15418 (RPS6KA1) , P17612 (PRKACA) , Q13131 (PRKAA1) , P17252 (PRKCA) , P49137 (MAPKAPK2) , P31749 (AKT1) | Uniprot |
| T463 | Phosphorylation | Uniprot | |
| S467 | Phosphorylation | Uniprot | |
| T471 | Phosphorylation | Uniprot | |
| S478 | Phosphorylation | Uniprot |
研究背景
Synthesis and degradation of fructose 2,6-bisphosphate.
Phosphorylation by AMPK stimulates activity.
Ubiquitous.
In the C-terminal section; belongs to the phosphoglycerate mutase family.
研究領域
· Environmental Information Processing > Signal transduction > HIF-1 signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > AMPK signaling pathway. (View pathway)
· Metabolism > Carbohydrate metabolism > Fructose and mannose metabolism.
参考文献
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