Phospho-Kir6.2 (Thr224) Antibody - #AF3590
| 製品: | Phospho-Kir6.2 (Thr224) Antibody |
| カタログ: | AF3590 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-Kir6.2 (Thr224) |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 44kD(Calculated). |
| ユニプロット: | Q14654 |
| RRID: | AB_2846904 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF3590, RRID:AB_2846904.
折りたたみ／展開
ATP sensitive inward rectifier potassium channel 11; Beta cell inward rectifier subunit; BIR; HHF 2; HHF2; IKATP; Inward rectifier K(+) channel Kir6.2; Inwardly rectifying potassium channel KIR6.2; IRK 11; IRK11; KCNJ11; Kir 6.2; Kir6.2; MGC133230; PHHI; Potassium channel inwardly rectifing subfamily J member 11; Potassium channel, inwardly rectifying subfamily J member 11; Potassium inwardly rectifying channel J11; TNDM 3; TNDM3;
免疫原
A synthesized peptide derived from human Kir6.2 around the phosphorylation site of Thr224.
- Q14654 KCJ11_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALTLASARGPLRKRSVPMAKAKPKFSISPDSLS
PTMs - Q14654 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T180 | Phosphorylation | Q9UQM7 (CAMK2A) | Uniprot |
| S208 | Phosphorylation | Uniprot | |
| T224 | Phosphorylation | Q9UQM7 (CAMK2A) , Q13557 (CAMK2D) | Uniprot |
| K332 | Ubiquitination | Uniprot | |
| T341 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| S372 | Phosphorylation | Uniprot | |
| S385 | Phosphorylation | P28482 (MAPK1) | Uniprot |
研究背景
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity.
Membrane>Multi-pass membrane protein.
Interacts with ABCC8/SUR. Interacts with ABCC9/SUR2.
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
研究領域
· Human Diseases > Endocrine and metabolic diseases > Type II diabetes mellitus.
· Organismal Systems > Endocrine system > Insulin secretion. (View pathway)
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