Phospho-MUNC-18a (Ser516) Antibody - #AF3640
| 製品: | Phospho-MUNC-18a (Ser516) Antibody |
| カタログ: | AF3640 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-MUNC-18a (Ser516) |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 68kD(Calculated). |
| ユニプロット: | P61764 |
| RRID: | AB_2846954 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF3640, RRID:AB_2846954.
折りたたみ／展開
FLJ37475; Munc 18 1; Munc 18a; MUNC18 1; N-Sec1; Neuronal SEC1; NSec1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; Rb sec1; RBSEC1; STXB1_HUMAN; STXBP1; Syntaxin binding protein 1; Syntaxin-binding protein 1; Unc 18 homolog; Unc 18A; Unc-18A; Unc18 1; UNC18; Unc18-1;
免疫原
A synthesized peptide derived from human MUNC-18a around the phosphorylation site of Ser516.
- P61764 STXB1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPQKLLDTLKKLNKTDEEISS
PTMs - P61764 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K7 | Ubiquitination | Uniprot | |
| K13 | Ubiquitination | Uniprot | |
| S70 | Phosphorylation | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| Y145 | Phosphorylation | Uniprot | |
| K184 | Ubiquitination | Uniprot | |
| K196 | Ubiquitination | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| K294 | Ubiquitination | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| S313 | Phosphorylation | Uniprot | |
| K314 | Ubiquitination | Uniprot | |
| K321 | Methylation | Uniprot | |
| K321 | Ubiquitination | Uniprot | |
| K332 | Ubiquitination | Uniprot | |
| K333 | Ubiquitination | Uniprot | |
| Y337 | Phosphorylation | Uniprot | |
| K339 | Ubiquitination | Uniprot | |
| K364 | Ubiquitination | Uniprot | |
| T376 | Phosphorylation | Uniprot | |
| K382 | Ubiquitination | Uniprot | |
| S454 | Phosphorylation | Uniprot | |
| T455 | Phosphorylation | Uniprot | |
| Y473 | Phosphorylation | Uniprot | |
| T479 | Phosphorylation | Q13627 (DYRK1A) | Uniprot |
| T489 | Phosphorylation | Uniprot | |
| S507 | Phosphorylation | Uniprot | |
| S509 | Phosphorylation | Uniprot | |
| S516 | Phosphorylation | Uniprot | |
| Y531 | Phosphorylation | Uniprot | |
| T574 | Phosphorylation | Uniprot | |
| K587 | Ubiquitination | Uniprot | |
| S593 | Phosphorylation | Uniprot | |
| S594 | Phosphorylation | Uniprot |
研究背景
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
Cytoplasm>Cytosol. Membrane>Peripheral membrane protein.
Brain and spinal cord. Highly enriched in axons.
Interacts with SYTL4 (By similarity). Interacts with STX1A. Interacts with alpha-synuclein/SNCA; this interaction controls SNCA self-replicating aggregation. Interacts with RAB3A; this interaction promotes RAB3A dissociation from the vesicle membrane (By similarity). Interacts with CABP5 (By similarity).
Belongs to the STXBP/unc-18/SEC1 family.
研究領域
· Organismal Systems > Nervous system > Synaptic vesicle cycle.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.