Phospho-FOXL2 (Ser263) Antibody - #AF3649
| 製品: | Phospho-FOXL2 (Ser263) Antibody |
| カタログ: | AF3649 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-FOXL2 (Ser263) |
| アプリケーション: | IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 39kD(Calculated). |
| ユニプロット: | P58012 |
| RRID: | AB_2846963 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF3649, RRID:AB_2846963.
折りたたみ／展開
Blepharophimosis; Blepharophimosis epicanthus inversus and ptosis 1; Blepharophimosis epicanthus inversus and ptosis; BPES 1; BPES; BPES1; Epicanthus inversus and ptosis 1; Forkhead box L2; Forkhead box protein L2; Forkhead transcription factor FOXL2; FOX L2; FOXL 2; FOXL2; FOXL2_HUMAN; PFRK; PINTO; PITUITARY FORKHEAD FACTOR; POF 3; POF3;
免疫原
A synthesized peptide derived from human FOXL2 around the phosphorylation site of Ser263.
In addition to its expression in the developing eyelid, it is transcribed very early in somatic cells of the developing gonad (before sex determination) and its expression persists in the follicular cells of the adult ovary.
- P58012 FOXL2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMASYPEPEDAAGALLAPETGRTVKEPEGPPPSPGKGGGGGGGTAPEKPDPAQKPPYSYVALIAMAIRESAEKRLTLSGIYQYIIAKFPFYEKNKKGWQNSIRHNLSLNECFIKVPREGGGERKGNYWTLDPACEDMFEKGNYRRRRRMKRPFRPPPAHFQPGKGLFGAGGAAGGCGVAGAGADGYGYLAPPKYLQSGFLNNSWPLPQPPSPMPYASCQMAAAAAAAAAAAAAAGPGSPGAAAVVKGLAGPAASYGPYTRVQSMALPPGVVNSYNGLGGPPAAPPPPPHPHPHPHAHHLHAAAAPPPAPPHHGAAAPPPGQLSPASPATAAPPAPAPTSAPGLQFACARQPELAMMHCSYWDHDSKTGALHSRLDL
PTMs - P58012 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S4 | Phosphorylation | Uniprot | |
| Y5 | Phosphorylation | Uniprot | |
| K25 | Sumoylation | Uniprot | |
| S33 | Phosphorylation | P49841 (GSK3B) | Uniprot |
| Y81 | Phosphorylation | Uniprot | |
| Y83 | Phosphorylation | Uniprot | |
| Y91 | Phosphorylation | Uniprot | |
| K96 | Acetylation | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| S101 | Phosphorylation | Uniprot | |
| S107 | Phosphorylation | Uniprot | |
| K114 | Sumoylation | Uniprot | |
| Y127 | Phosphorylation | Uniprot | |
| K140 | Acetylation | Uniprot | |
| Y186 | Phosphorylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| Y215 | Phosphorylation | Uniprot | |
| S238 | Phosphorylation | Uniprot | |
| Y258 | Phosphorylation | Uniprot | |
| S263 | Phosphorylation | Q13153 (PAK1) | Uniprot |
| S323 | Phosphorylation | Uniprot | |
| S326 | Phosphorylation | Uniprot | |
| T329 | Phosphorylation | Uniprot | |
| K366 | Acetylation | Uniprot |
研究背景
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
Sumoylated with SUMO1; sumoylation is required for transcriptional repression activity.
Nucleus.
In addition to its expression in the developing eyelid, it is transcribed very early in somatic cells of the developing gonad (before sex determination) and its expression persists in the follicular cells of the adult ovary.
Interacts with ESR1 (By similarity). Interacts with SMAD3 (By similarity). Interacts with DDX20. Interacts with UBE2I/UBC9.
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