Phospho-CD50/ICAM-3 (Ser518) Antibody - #AF3682
| 製品: | Phospho-CD50/ICAM-3 (Ser518) Antibody |
| カタログ: | AF3682 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-CD50/ICAM-3 (Ser518) |
| アプリケーション: | ELISA(peptide) |
| 反応性: | Human |
| 分子量: | 60kD(Calculated). |
| ユニプロット: | P32942 |
| RRID: | AB_2846996 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF3682, RRID:AB_2846996.
折りたたみ／展開
CD50; CDW 50; CDw50; ICAM 3; ICAM-3; ICAM-R; ICAM3; ICAM3_HUMAN; ICAMR; Intercellular adhesion molecule 3;
免疫原
A synthesized peptide derived from human CD50/ICAM-3 around the phosphorylation site of Ser518.
- P32942 ICAM3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSSEKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTSMQPTEAMGEEPSRAE
PTMs - P32942 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N52 | N-Glycosylation | Uniprot | |
| N84 | N-Glycosylation | Uniprot | |
| N87 | N-Glycosylation | Uniprot | |
| N110 | N-Glycosylation | Uniprot | |
| N134 | N-Glycosylation | Uniprot | |
| T151 | Phosphorylation | Uniprot | |
| N206 | N-Glycosylation | Uniprot | |
| N295 | N-Glycosylation | Uniprot | |
| N363 | N-Glycosylation | Uniprot | |
| K401 | Ubiquitination | Uniprot | |
| K412 | Ubiquitination | Uniprot | |
| S516 | Phosphorylation | Uniprot | |
| S518 | Phosphorylation | Q04759 (PRKCQ) | Uniprot |
| Y519 | Phosphorylation | Uniprot | |
| S525 | Phosphorylation | Uniprot | |
| T526 | Phosphorylation | Uniprot | |
| Y527 | Phosphorylation | Uniprot | |
| T531 | Phosphorylation | Uniprot | |
| S532 | Phosphorylation | Uniprot | |
| T536 | Phosphorylation | Uniprot |
研究背景
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages.
Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.
N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains.
Membrane>Single-pass type I membrane protein.
Leukocytes.
Interacts with moesin/MSN.
Belongs to the immunoglobulin superfamily. ICAM family.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
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