製品: Phospho-MSP/MST1 (Thr367) Antibody
カタログ: AF3689
タンパク質の説明: Rabbit polyclonal antibody to Phospho-MSP/MST1 (Thr367)
アプリケーション: IHC
反応性: Human, Mouse, Rat
分子量: 90-100kD; 80kD(Calculated).
ユニプロット: P26927
RRID: AB_2847003

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製品説明

ソース:
Rabbit
アプリケーション:
IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
Phospho-MST1 (Thr367) Antibody detects endogenous levels of MST1 only when phosphorylated at Thr367.
RRID:
AB_2847003
引用形式: Affinity Biosciences Cat# AF3689, RRID:AB_2847003.
コンジュゲート:
Unconjugated.
精製:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

D3F15S2; DNF15S2; Hepatocyte growth factor like protein alpha chain; Hepatocyte growth factor like protein; Hepatocyte growth factor like protein beta chain; Hepatocyte growth factor like protein homolog; Hepatocyte growth factor-like protein beta chain; HGFL; HGFL_HUMAN; Macrophage stimulating 1 (hepatocyte growth factor like); Macrophage stimulatory protein; Macrophage-stimulating protein; MSP; MST1; NF15S2; OTTHUMP00000208927;

免疫原

免疫原:

A synthesized peptide derived from human MST1 around the phosphorylation site of Thr367.

Uniprot:
遺伝子(ID):
タンパク質配列:
MGWLPLLLLLTQCLGVPGQRSPLNDFQVLRGTELQHLLHAVVPGPWQEDVADAEECAGRCGPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLFQKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTLRNGLEENFCRNPDGDPGGPWCYTTDPAVRFQSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSERPWCYTTDPQIEREFCDLPRCGSEAQPRQEATTVSCFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFTLRPGMRAAFCYQIRRCTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDPRTPFDYCALRRCADDQPPSILDPPDQVQFEKCGKRVDRLDQRRSKLRVVGGHPGNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSSCHMPLTGYEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPSGSQLVLLKLERSVTLNQRVALICLPPEWYVVPPGTKCEIAGWGETKGTGNDTVLNVALLNVISNQECNIKHRGRVRESEMCTEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVMRLG

PTMs - P26927 基板として

Site PTM Type Enzyme
S185 Phosphorylation
Y199 Phosphorylation
N296 N-Glycosylation
S480 Phosphorylation
K573 Ubiquitination
N615 N-Glycosylation

PTMs - P26927 酵素として

Substrate Site Source
P33778 (HIST1H2BB) S15 Uniprot
Q13043 (STK4) T183 Uniprot
Q15208 (STK38) T444 Uniprot

研究背景

PTMs:

Cleaved after Arg-483, probably by HPN/Hepsin, to yield the active form consisting of two disulfide-linked chains.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts (via beta chain) with MST1R (via SEMA domain).

タンパク質ファミリー:

Belongs to the peptidase S1 family. Plasminogen subfamily.

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