Phospho-Tryptophan Hydroxylase (Ser58) Antibody - #AF3714

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製品: Phospho-Tryptophan Hydroxylase (Ser58) Antibody
カタログ: AF3714
タンパク質の説明: Rabbit polyclonal antibody to Phospho-Tryptophan Hydroxylase (Ser58)
アプリケーション: IHC
反応性: Human, Mouse, Rat
分子量: 51kD(Calculated).
ユニプロット: P17752
RRID: AB_2847028

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MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
Phospho-Tryptophan Hydroxylase (Ser58) Antibody detects endogenous levels of Tryptophan Hydroxylase only when phosphorylated at Ser58.
RRID:
AB_2847028
引用形式: Affinity Biosciences Cat# AF3714, RRID:AB_2847028.
コンジュゲート:
Unconjugated.
精製:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Indoleacetic acid 5 hydroxylase; L tryptophan hydroxylase; MGC119994; TPH 1; TPH; TPH1; TPH1_HUMAN; TPRH; TRPH; Tryptophan 5 hydroxylase 1; Tryptophan 5 monooxygenase 1; Tryptophan 5 monooxygenase; Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; Tryptophan hydroxylase 1;

免疫原

免疫原:

A synthesized peptide derived from human Tryptophan Hydroxylase around the phosphorylation site of Ser58.

Uniprot:

P17752(TPH1_HUMAN) >>Visit HPA database.

遺伝子(ID):
TPH1(7166)
発現特異性:
P17752 TPH1_HUMAN:

Isoform 2 seems to be less widely expressed than isoform 1.

タンパク質配列:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI

PTMs - P17752 基板として

Site PTM Type Enzyme
K33 Acetylation
S58 Phosphorylation
T225 Phosphorylation
S228 Phosphorylation
S260 Phosphorylation
Y373 Phosphorylation
Y401 Phosphorylation
Y404 Phosphorylation

研究背景

組織特異性:

Isoform 2 seems to be less widely expressed than isoform 1.

サブユニット構造:

Homotetramer.

タンパク質ファミリー:

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

研究領域

· Metabolism > Amino acid metabolism > Tryptophan metabolism.

· Metabolism > Metabolism of cofactors and vitamins > Folate biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Nervous system > Serotonergic synapse.

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