Phospho-Profilin 1 (Ser138) Antibody - #AF3739
| 製品: | Phospho-Profilin 1 (Ser138) Antibody |
| カタログ: | AF3739 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-Profilin 1 (Ser138) |
| アプリケーション: | ELISA(peptide) |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 15kD(Calculated). |
| ユニプロット: | P07737 |
| RRID: | AB_2847053 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF3739, RRID:AB_2847053.
折りたたみ／展開
Actin binding protein; ALS18; Epididymis tissue protein Li 184a; OTTHUMP00000125244; PFN 1; Pfn; PFN1; PROF1_HUMAN; Profilin I; Profilin-1; Profilin1; ProfilinI;
免疫原
A synthesized peptide derived from human Profilin 1 around the phosphorylation site of Ser138.
- P07737 PROF1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGWNAYIDNLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVNITPAEVGVLVGKDRSSFYVNGLTLGGQKCSVIRDSLLQDGEFSMDLRTKSTGGAPTFNVTVTKTDKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY
PTMs - P07737 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| Y7 | Phosphorylation | Uniprot | |
| T16 | Phosphorylation | Uniprot | |
| Y25 | Phosphorylation | Uniprot | |
| K26 | Ubiquitination | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| K38 | Acetylation | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| T39 | Phosphorylation | Uniprot | |
| T44 | Phosphorylation | Uniprot | |
| K54 | Acetylation | Uniprot | |
| K54 | Methylation | Uniprot | |
| K54 | Ubiquitination | Uniprot | |
| R56 | Methylation | Uniprot | |
| S57 | Phosphorylation | Uniprot | |
| Y60 | Phosphorylation | Uniprot | |
| T65 | Phosphorylation | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| S85 | Phosphorylation | Uniprot | |
| T90 | Phosphorylation | Uniprot | |
| K91 | Acetylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| S92 | Phosphorylation | Uniprot | |
| T93 | Phosphorylation | Uniprot | |
| T98 | Phosphorylation | Uniprot | |
| T102 | Phosphorylation | Uniprot | |
| T104 | Phosphorylation | Uniprot | |
| K105 | Acetylation | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| T106 | Phosphorylation | Uniprot | |
| K108 | Acetylation | Uniprot | |
| K108 | Ubiquitination | Uniprot | |
| T109 | Phosphorylation | Uniprot | |
| K116 | Ubiquitination | Uniprot | |
| K126 | Acetylation | Uniprot | |
| K126 | Ubiquitination | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| C128 | S-Nitrosylation | Uniprot | |
| Y129 | Phosphorylation | P12931 (SRC) , P35968 (KDR) | Uniprot |
| S133 | Phosphorylation | Uniprot | |
| S138 | Phosphorylation | Q13464 (ROCK1) | Uniprot |
| Y140 | Phosphorylation | Uniprot |
研究背景
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation.
Cytoplasm>Cytoskeleton.
Expressed in epididymis (at protein level).
Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio. Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with VASP. Interacts with HTT.
Belongs to the profilin family.
研究領域
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Environmental Information Processing > Signal transduction > Rap1 signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Shigellosis.
· Human Diseases > Infectious diseases: Bacterial > Salmonella infection.
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