Phospho-SLC31A1 / CTR1 (Thr114) Antibody - #AF3773
| 製品: | Phospho-SLC31A1 / CTR1 (Thr114) Antibody |
| カタログ: | AF3773 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-SLC31A1 / CTR1 (Thr114) |
| アプリケーション: | ELISA(peptide) |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 21kD(Calculated). |
| ユニプロット: | O15431 |
| RRID: | AB_2847087 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF3773, RRID:AB_2847087.
折りたたみ／展開
Copper transport 1 homolog; Copper transporter 1; COPT1; COPT1_HUMAN; CTR1; hCTR1; High affinity copper uptake protein 1; SLC31A1; solute carrier family 31 (copper tansporters) member 1; Solute carrier family 31 member 1;
免疫原
A synthesized peptide derived from human SLC31A1 / CTR1 around the phosphorylation site of Thr114.
- O15431 COPT1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSGLVINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH
PTMs - O15431 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S4 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| Y11 | Phosphorylation | Uniprot | |
| N15 | N-Glycosylation | Uniprot | |
| T27 | O-Glycosylation | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| S105 | Phosphorylation | Uniprot | |
| T114 | Phosphorylation | Uniprot |
研究背景
High-affinity, saturable copper transporter involved in dietary copper uptake.
O-Glycosylation at Thr-27 protects from proteolytic cleavage in the N-terminal extracellular domain.
Cell membrane>Multi-pass membrane protein.
Note: Localizes to the apical membrane in intestinal epithelial cells.
Homotrimer.
Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
研究領域
· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.
· Organismal Systems > Digestive system > Mineral absorption.
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