Phospho-SGK2 (Thr253) Antibody - #AF3791
| 製品: | Phospho-SGK2 (Thr253) Antibody |
| カタログ: | AF3791 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-SGK2 (Thr253) |
| アプリケーション: | WB IHC |
| 反応性: | Human, Rat |
| 分子量: | 48kD(Calculated). |
| ユニプロット: | Q9HBY8 |
| RRID: | AB_2847105 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF3791, RRID:AB_2847105.
折りたたみ／展開
DJ138B7.2; H SGK2; HSGK2; Serine/threonine protein kinase SGK2; Serine/threonine-protein kinase Sgk2; Serum/glucocorticoid regulated kinase 2; Serum/glucocorticoid-regulated kinase 2; SGK2; SGK2_HUMAN;
免疫原
A synthesized peptide derived from human SGK2 around the phosphorylation site of Thr253.
- Q9HBY8 SGK2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MQGLLTSGRKPSGGGRCTGRGGWRGQWCLKPWMGGADPPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPEDDDILDC
研究背景
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.
Activated by phosphorylation on Ser-416 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-253.
Cytoplasm. Nucleus.
Highly expressed in liver, kidney and pancreas, and at lower levels in brain.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
研究領域
· Environmental Information Processing > Signal transduction > FoxO signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
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