Phospho-BCKDHA (Ser292/Ser337) Antibody - #AF3826
| 製品: | Phospho-BCKDHA (Ser292/Ser337) Antibody |
| カタログ: | AF3826 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-BCKDHA (Ser292/Ser337) |
| アプリケーション: | IHC |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 50kD(Calculated). |
| ユニプロット: | P12694 |
| RRID: | AB_2847140 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF3826, RRID:AB_2847140.
折りたたみ／展開
;Branched chain alpha keto acid dehydrogenase E1 component alpha polypeptide; FLJ45695; OVD1A; 2 oxoisovalerate dehydrogenase (lipoamide); 2 oxoisovalerate dehydrogenase subunit alpha, mitochondrial; 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; BCKDE1A; BCKDH E1 alpha; BCKDH E1-alpha; BCKDHA; Branched chain alpha keto acid dehydrogenase E1 component alpha chain; Branched chain keto acid dehydrogenase E1 alpha polypeptide; Branched chain keto acid dehydrogenase E1, alpha polypeptide (maple syrup urine disease); Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; MSU; MSUD1; ODBA_HUMAN;
免疫原
A synthesized peptide derived from human BCKDHA around the phosphorylation site of Ser292/337.
- P12694 ODBA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAVAIAAARVWRLNRGLSQAALLLLRQPGARGLARSHPPRQQQQFSSLDDKPQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKLYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDLVFGQYREAGVLMYRDYPLELFMAQCYGNISDLGKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYLLSQGWWDEEQEKAWRKQSRRKVMEAFEQAERKPKPNPNLLFSDVYQEMPAQLRKQQESLARHLQTYGEHYPLDHFDK
PTMs - P12694 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S46 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| Y106 | Phosphorylation | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| T114 | Phosphorylation | Uniprot | |
| R117 | Methylation | Uniprot | |
| S206 | Phosphorylation | Uniprot | |
| S207 | Phosphorylation | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| S295 | Phosphorylation | Uniprot | |
| Y307 | Phosphorylation | Uniprot | |
| K311 | Ubiquitination | Uniprot | |
| S337 | Phosphorylation | O14874 (BCKDK) | Uniprot |
| T338 | Phosphorylation | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| S342 | Phosphorylation | Uniprot | |
| S343 | Phosphorylation | Uniprot | |
| Y345 | Phosphorylation | Uniprot | |
| S347 | Phosphorylation | Uniprot | |
| Y353 | Phosphorylation | Uniprot | |
| K356 | Ubiquitination | Uniprot | |
| K445 | Acetylation | Uniprot |
研究背景
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
Mitochondrion matrix.
Heterotetramer of alpha and beta chains.
Belongs to the BCKDHA family.
研究領域
· Metabolism > Amino acid metabolism > Valine, leucine and isoleucine degradation.
· Metabolism > Carbohydrate metabolism > Propanoate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.