Phospho-MLKL (Ser347) Antibody - #AF3903

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製品: Phospho-MLKL (Ser347) Antibody
カタログ: AF3903
タンパク質の説明: Rabbit polyclonal antibody to Phospho-MLKL (Ser347)
アプリケーション: IHC IF/ICC
反応性: Human, Mouse
分子量: 36kD(Calculated).
ユニプロット: Q9D2Y5
RRID: AB_2847217

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MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
クローナリティ:
Polyclonal
特異性:
Phospho-MLKL (Ser347) Antibody detects endogenous levels of MLKL only when phosphorylated at Ser347.
RRID:
AB_2847217
引用形式: Affinity Biosciences Cat# AF3903, RRID:AB_2847217.
コンジュゲート:
Unconjugated.
精製:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

免疫原

免疫原:

A synthesized peptide derived from mouse MLKL around the phosphorylation site of Ser347.

Uniprot:

Q9D2Y5(SNX20_MOUSE) >>Visit HPA database.

タンパク質配列:
MASPEHPGSPGWRGPINQCRTRTRQEVLPPGPDLPCPGPEEAQDGPSSNSSMTTRELQEHWQKEKSRWKHVRLLFEIASARIEERKVSKFVMYQVVVIQTGSFDSDKAVVERRYSDFERLQKALLKRFGPELEDVTFPRKRLTGNLSAETICERRRELREYLRLLYAVRAVRRSREFLDFLTRPELREAFGCLRAGQYARALELLGRALPLQEKLTAHCPSAAVPALCAALVCLRDLERPAEAFAVGERALRCLRTRENHRYYAPLLDAMVRLAYALGKDFAALQSRLDENQLRRPTHRDATLKELTVREYLS

研究背景

機能:

May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, nor on SELPLG-mediated cell-cell adhesion.

細胞の位置付け:

Early endosome membrane>Peripheral membrane protein>Cytoplasmic side. Cell membrane. Cytoplasm. Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Interacts with SELPLG (By similarity). Interaction with SELPLG is controversial and was not detected in.

タンパク質ファミリー:

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for localization to the endosomes.

Belongs to the sorting nexin family.

Restrictive clause

 

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For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.