SIK2 Antibody - #AF6541
| 製品: | SIK2 Antibody |
| カタログ: | AF6541 |
| タンパク質の説明: | Rabbit polyclonal antibody to SIK2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 104kD(Calculated). |
| ユニプロット: | Q9H0K1 |
| RRID: | AB_2847265 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF6541, RRID:AB_2847265.
折りたたみ／展開
DKFZp434K1115; EC 2.7.11.1; KIAA0781; LOH11CR1I; QIK; Qin induced kinase; Qin-induced kinase; Salt inducible kinase 2; Salt inducible protein kinase 2; Salt inducible serine/threonine kinase 2; Salt-inducible protein kinase 2; Serine/threonine protein kinase SIK2; Serine/threonine protein kinase SNF1 like kinase 2; Serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; SIK 2; SIK-2; SIK2; SIK2_HUMAN; SNF1 like kinase; SNF1 like kinase 2; SNF1LK2;
免疫原
A synthesized peptide derived from human SIK2.
- Q9H0K1 SIK2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN
PTMs - Q9H0K1 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T25 | Phosphorylation | Uniprot | |
| K28 | Ubiquitination | Uniprot | |
| K43 | Ubiquitination | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| K53 | Acetylation | Uniprot | |
| K53 | Ubiquitination | Uniprot | |
| K63 | Ubiquitination | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| K144 | Ubiquitination | Uniprot | |
| K168 | Sumoylation | Uniprot | |
| T175 | Phosphorylation | Q15831 (STK11) | Uniprot |
| K266 | Ubiquitination | Uniprot | |
| K313 | Ubiquitination | Uniprot | |
| S342 | Phosphorylation | Uniprot | |
| S343 | Phosphorylation | Uniprot | |
| S358 | Phosphorylation | P31751 (AKT2) , P17612 (PRKACA) | Uniprot |
| T359 | Phosphorylation | Uniprot | |
| S379 | Phosphorylation | Uniprot | |
| T484 | Phosphorylation | Uniprot | |
| S486 | Phosphorylation | Uniprot | |
| S512 | Phosphorylation | Uniprot | |
| S534 | Phosphorylation | Uniprot | |
| K536 | Ubiquitination | Uniprot | |
| S545 | Phosphorylation | Uniprot | |
| R547 | Methylation | Uniprot | |
| S576 | Phosphorylation | Uniprot | |
| S587 | Phosphorylation | Uniprot | |
| T589 | Phosphorylation | Uniprot | |
| S590 | Phosphorylation | Uniprot | |
| K686 | Ubiquitination | Uniprot | |
| K692 | Ubiquitination | Uniprot | |
| Y700 | Phosphorylation | Uniprot | |
| K702 | Ubiquitination | Uniprot |
PTMs - Q9H0K1 酵素として
研究背景
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6.
Cytoplasm.
Interacts with and phosphorylates TORC2/CRTC2.
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
研究領域
· Organismal Systems > Endocrine system > Glucagon signaling pathway.
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