CDKN2A/p16INK4a Antibody - #AF6667
| 製品: | CDKN2A/p16INK4a Antibody |
| カタログ: | AF6667 |
| タンパク質の説明: | Rabbit polyclonal antibody to CDKN2A/p16INK4a |
| アプリケーション: | ELISA(peptide) |
| 反応性: | Human |
| 分子量: | 17kD(Calculated). |
| ユニプロット: | P42771 |
| RRID: | AB_2847390 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF6667, RRID:AB_2847390.
折りたたみ／展開
Cyclin-dependent kinase inhibitor 2A;Cyclin-dependent kinase 4 inhibitor A;CDK4I;Multiple tumor suppressor 1;MTS-1;p16-INK4a;p16-INK4;p16INK4A;CDKN2A;CDKN2;MTS1;
免疫原
A synthesized peptide derived from human CDKN2A/p16INK4a.
Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.
- P42771 CDN2A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSNHARIDAAEGPSDIPD
PTMs - P42771 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S7 | Phosphorylation | Q13535 (ATR) | Uniprot |
| S8 | Phosphorylation | O14920 (IKBKB) , Q13535 (ATR) | Uniprot |
| Y44 | Phosphorylation | Uniprot | |
| R99 | Methylation | Uniprot | |
| R131 | Methylation | Uniprot | |
| R138 | Methylation | Uniprot | |
| S140 | Phosphorylation | Q13535 (ATR) | Uniprot |
| S152 | Phosphorylation | Q13535 (ATR) | Uniprot |
研究背景
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Phosphorylation seems to increase interaction with CDK4.
Cytoplasm. Nucleus.
Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.
Heterodimer with CDK4 or CDK6. Predominant p16 complexes contained CDK6. Interacts with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2.
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
研究領域
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
· Cellular Processes > Cell growth and death > p53 signaling pathway. (View pathway)
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
· Human Diseases > Drug resistance: Antineoplastic > Endocrine resistance.
· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > Viral carcinogenesis.
· Human Diseases > Cancers: Overview > MicroRNAs in cancer.
· Human Diseases > Cancers: Specific types > Pancreatic cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Glioma. (View pathway)
· Human Diseases > Cancers: Specific types > Melanoma. (View pathway)
· Human Diseases > Cancers: Specific types > Bladder cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Chronic myeloid leukemia. (View pathway)
· Human Diseases > Cancers: Specific types > Non-small cell lung cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma. (View pathway)
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