CD171/N-CAML1 Antibody - #AF6683
| 製品: | CD171/N-CAML1 Antibody |
| カタログ: | AF6683 |
| タンパク質の説明: | Rabbit polyclonal antibody to CD171/N-CAML1 |
| アプリケーション: | ELISA(peptide) |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 140kD(Calculated). |
| ユニプロット: | P32004 |
| RRID: | AB_2847406 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF6683, RRID:AB_2847406.
折りたたみ／展開
Antigen identified by monoclonal antibody R1; CAML1; CD171; CD171 antigen; HSAS; HSAS1; Hyd; L1; L1 cell adhesion molecule; L1-NCAM; L1cam; L1CAM_HUMAN; MASA; MIC5; N CAML1; N-CAM-L1; NCAM-L1; NCAML1; Nerve-growth factor-inducible large external glycoprotein; Neural cell adhesion molecule L1; NILE; OTTHUMP00000025992; S10; SPG1;
免疫原
A synthesized peptide derived from human CD171/N-CAML1.
- P32004 L1CAM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVVALRYVWPLLLCSPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLPPAGFATEGWFIGFVSAIILLLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYRSLESDNEEKAFGSSQPSLNGDIKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPINPAVALE
PTMs - P32004 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Phosphorylation | Uniprot | ||
| K56 | Ubiquitination | Uniprot | |
| K77 | Ubiquitination | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K144 | Ubiquitination | Uniprot | |
| S153 | Phosphorylation | Uniprot | |
| S163 | Phosphorylation | Uniprot | |
| K180 | Ubiquitination | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| K230 | Ubiquitination | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| K338 | Ubiquitination | Uniprot | |
| K378 | Ubiquitination | Uniprot | |
| Y418 | Phosphorylation | Uniprot | |
| Y420 | Phosphorylation | Uniprot | |
| K515 | Ubiquitination | Uniprot | |
| T518 | Phosphorylation | Uniprot | |
| T521 | Phosphorylation | Uniprot | |
| T527 | Phosphorylation | Uniprot | |
| K530 | Acetylation | Uniprot | |
| K568 | Ubiquitination | Uniprot | |
| S611 | Phosphorylation | Uniprot | |
| K655 | Ubiquitination | Uniprot | |
| K661 | Ubiquitination | Uniprot | |
| K667 | Ubiquitination | Uniprot | |
| N671 | N-Glycosylation | Uniprot | |
| K694 | Ubiquitination | Uniprot | |
| K716 | Ubiquitination | Uniprot | |
| Y784 | Phosphorylation | Uniprot | |
| K998 | Ubiquitination | Uniprot | |
| K1150 | Ubiquitination | Uniprot | |
| Y1151 | Phosphorylation | Uniprot | |
| S1152 | Phosphorylation | Uniprot | |
| K1154 | Ubiquitination | Uniprot | |
| K1156 | Ubiquitination | Uniprot | |
| S1163 | Phosphorylation | Uniprot | |
| K1169 | Ubiquitination | Uniprot | |
| T1172 | Phosphorylation | P68400 (CSNK2A1) , P17252 (PRKCA) | Uniprot |
| Y1176 | Phosphorylation | P12931 (SRC) | Uniprot |
| S1181 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S1190 | Phosphorylation | Uniprot | |
| S1191 | Phosphorylation | Uniprot | |
| S1194 | Phosphorylation | Uniprot | |
| S1204 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| Y1211 | Phosphorylation | Uniprot | |
| Y1229 | Phosphorylation | P54753 (EPHB3) | Uniprot |
| K1235 | Ubiquitination | Uniprot | |
| S1243 | Phosphorylation | Uniprot | |
| S1244 | Phosphorylation | Uniprot | |
| T1247 | Phosphorylation | Uniprot | |
| S1248 | Phosphorylation | P28482 (MAPK1) | Uniprot |
研究背景
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
Cell membrane>Single-pass type I membrane protein. Cell projection>Growth cone. Cell projection>Axon. Cell projection>Dendrite.
Note: Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons (By similarity). In neurons, detected predominantly in axons and cell body, weak localization to dendrites (PubMed:20621658).
Interacts with SHTN1; the interaction occurs in axonal growth cones.
Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
· Organismal Systems > Development > Axon guidance. (View pathway)
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