GAP43 Antibody - #AF6715
| 製品: | GAP43 Antibody |
| カタログ: | AF6715 |
| タンパク質の説明: | Rabbit polyclonal antibody to GAP43 |
| アプリケーション: | IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 25kD(Calculated). |
| ユニプロット: | P17677 |
| RRID: | AB_2847438 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF6715, RRID:AB_2847438.
折りたたみ／展開
Axonal membrane protein GAP 43; Axonal membrane protein GAP-43; B 50; Calmodulin binding protein P 57; F1; GAP 43; GAP43; Growth Associated Protein 43; Growth-associated protein 43; Nerve Growth Related Peptide; Nerve growth related peptide GAP43; NEUM_HUMAN; Neural phosphoprotein B 50; Neural phosphoprotein B-50; Neuromodulin; Neuron growth associated protein 43; PP46; Protein F1; QtrA-11580; QtrA-13071;
免疫原
A synthesized peptide derived from human GAP43.
- P17677 NEUM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLCCMRRTKQVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA
PTMs - P17677 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T36 | Phosphorylation | Uniprot | |
| K37 | Ubiquitination | Uniprot | |
| S41 | Phosphorylation | Q02156 (PRKCE) | Uniprot |
| T107 | Phosphorylation | Uniprot | |
| S109 | Phosphorylation | Uniprot | |
| S131 | Phosphorylation | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| T144 | Phosphorylation | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| T148 | Phosphorylation | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| T181 | Phosphorylation | Uniprot | |
| K216 | Methylation | Uniprot |
研究背景
This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).
Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2.
Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cell projection>Growth cone membrane>Peripheral membrane protein>Cytoplasmic side. Cell junction>Synapse. Cell projection>Filopodium membrane>Peripheral membrane protein. Perikaryon. Cell projection>Dendrite. Cell projection>Axon. Cytoplasm.
Note: Cytoplasmic surface of growth cone and synaptic plasma membranes.
Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By similarity). Interacts (via IQ domain) with calmodulin (By similarity). Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By similarity).
Belongs to the neuromodulin family.
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