LETM1 Antibody - #AF6759
| 製品: | LETM1 Antibody |
| カタログ: | AF6759 |
| タンパク質の説明: | Rabbit polyclonal antibody to LETM1 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse |
| 分子量: | 90kD; 83kD(Calculated). |
| ユニプロット: | O95202 |
| RRID: | AB_2847482 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF6759, RRID:AB_2847482.
折りたたみ／展開
LETM 1; LETM1 and EF hand domain containing protein 1, mitochondrial; LETM1 and EF-hand domain-containing protein 1; Letm1; LETM1_HUMAN; Leucine zipper EF hand containing transmembrane protein 1; Leucine zipper-EF-hand-containing transmembrane protein 1; Mdm38 homolog; mitochondrial;
免疫原
- O95202 LETM1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS
PTMs - O95202 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S3 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| Y141 | Phosphorylation | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| Y164 | Phosphorylation | Uniprot | |
| T175 | Phosphorylation | Uniprot | |
| S190 | Phosphorylation | Uniprot | |
| T192 | Phosphorylation | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| K257 | Ubiquitination | Uniprot | |
| K284 | Acetylation | Uniprot | |
| S287 | Phosphorylation | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| R307 | Methylation | Uniprot | |
| K373 | Ubiquitination | Uniprot | |
| R393 | Methylation | Uniprot | |
| Y579 | Phosphorylation | Uniprot | |
| S580 | Phosphorylation | Uniprot | |
| K597 | Acetylation | Uniprot | |
| S602 | Phosphorylation | Uniprot | |
| T643 | Phosphorylation | Uniprot | |
| S649 | Phosphorylation | Uniprot | |
| S666 | Phosphorylation | Uniprot | |
| K682 | Ubiquitination | Uniprot | |
| S739 | Phosphorylation | Uniprot |
研究背景
Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion. Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization. In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion.
Mitochondrion inner membrane>Single-pass membrane protein.
Homohexamer (By similarity). Can form 2 complexes: a major (300 kDa) and a minor complex (500-600 kDa). Interacts with BCS1L.
Belongs to the LETM1 family.
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