SCD1 Antibody - #AF6781
| 製品: | SCD1 Antibody |
| カタログ: | AF6781 |
| タンパク質の説明: | Rabbit polyclonal antibody to SCD1 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 分子量: | 41 kDa; 42kD(Calculated). |
| ユニプロット: | O00767 |
| RRID: | AB_2847504 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF6781, RRID:AB_2847504.
折りたたみ／展開
ACOD_HUMAN; Acyl-CoA desaturase; Delta(9)-desaturase; Delta-9 desaturase; Delta-9-Desaturase; FADS5; Fatty acid desaturase; PRO0998; SCD 1; SCD; SCD1; Stearoyl-CoA desaturase;
免疫原
A synthesized peptide derived from human SCD1.
Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung.
- O00767 ACOD_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
PTMs - O00767 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y14 | Phosphorylation | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| Y41 | Phosphorylation | Uniprot | |
| K51 | Sumoylation | Uniprot | |
| K51 | Ubiquitination | Uniprot | |
| Y55 | Phosphorylation | Uniprot | |
| Y59 | Phosphorylation | Uniprot | |
| K60 | Ubiquitination | Uniprot | |
| K62 | Ubiquitination | Uniprot | |
| K68 | Sumoylation | Uniprot | |
| K68 | Ubiquitination | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| T91 | Phosphorylation | Uniprot | |
| T95 | Phosphorylation | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| K196 | Ubiquitination | Uniprot | |
| S198 | Phosphorylation | Uniprot | |
| T199 | Phosphorylation | Uniprot | |
| S203 | Phosphorylation | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| K278 | Ubiquitination | Uniprot | |
| K338 | Ubiquitination | Uniprot | |
| K341 | Ubiquitination | Uniprot | |
| T351 | Phosphorylation | Uniprot | |
| K357 | Ubiquitination | Uniprot |
研究背景
Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).
Endoplasmic reticulum membrane>Multi-pass membrane protein.
Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung.
May self-associate and form homodimers.
The histidine box domains are involved in binding the catalytic metal ions.
Belongs to the fatty acid desaturase type 1 family.
研究領域
· Environmental Information Processing > Signal transduction > AMPK signaling pathway. (View pathway)
· Metabolism > Lipid metabolism > Biosynthesis of unsaturated fatty acids.
· Metabolism > Global and overview maps > Fatty acid metabolism.
· Organismal Systems > Endocrine system > PPAR signaling pathway.
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