SNAP23 Antibody - #AF6788
| 製品: | SNAP23 Antibody |
| カタログ: | AF6788 |
| タンパク質の説明: | Rabbit polyclonal antibody to SNAP23 |
| アプリケーション: | ELISA(peptide) |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 23kD(Calculated). |
| ユニプロット: | O00161 |
| RRID: | AB_2847511 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF6788, RRID:AB_2847511.
折りたたみ／展開
HsT17016; LS-B8340; SNAP 23; SNAP-23; SNAP23; SNAP23A; SNAP23B; SNP23_HUMAN; Synaptosomal associated protein 23; Synaptosomal associated protein 23kDa; Synaptosomal associated protein; Synaptosomal-associated protein 23; Vesicle membrane fusion protein SNAP 23; Vesicle membrane fusion protein SNAP23; Vesicle-membrane fusion protein SNAP-23;
免疫原
A synthesized peptide derived from human SNAP23.
- O00161 SNP23_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDNLSSEEIQQRAHQITDESLESTRRILGLAIESQDAGIKTITMLDEQKEQLNRIEEGLDQINKDMRETEKTLTELNKCCGLCVCPCNRTKNFESGKAYKTTWGDGGENSPCNVVSKQPGPVTNGQLQQPTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKDMALNIGNEIDAQNPQIKRITDKADTNRDRIDIANARAKKLIDS
PTMs - O00161 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S5 | Phosphorylation | Uniprot | |
| S6 | Phosphorylation | Uniprot | |
| T17 | Phosphorylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| S23 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| T24 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S34 | Phosphorylation | Uniprot | |
| K40 | Ubiquitination | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| K64 | Ubiquitination | Uniprot | |
| K71 | Ubiquitination | Uniprot | |
| T72 | Phosphorylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| S95 | Phosphorylation | P14618 (PKM) | Uniprot |
| K97 | Ubiquitination | Uniprot | |
| Y99 | Phosphorylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| T102 | Phosphorylation | Uniprot | |
| S110 | Phosphorylation | Uniprot | |
| C112 | S-Nitrosylation | Uniprot | |
| K117 | Ubiquitination | Uniprot | |
| S136 | Phosphorylation | Uniprot | |
| Y139 | Phosphorylation | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| T144 | Phosphorylation | Uniprot | |
| T157 | Phosphorylation | Uniprot | |
| S161 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| K185 | Ubiquitination | Uniprot | |
| K190 | Ubiquitination | Uniprot |
研究背景
Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.
Cell membrane>Peripheral membrane protein. Cell membrane>Lipid-anchor. Cell junction>Synapse>Synaptosome.
Note: Mainly localized to the plasma membrane.
Ubiquitous. Highest levels where found in placenta.
Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3. Found in a complex with VAMP8 and STX1A. Found in a complex with VAMP8 and STX4 in pancreas (By similarity). Interacts simultaneously with SNAPIN and SYN4 (By similarity). Interacts with STX1A (By similarity). Interacts with STX12 (By similarity). Interacts tightly to multiple syntaxins and synaptobrevins/VAMPs (By similarity). Interacts with ZDHHC13 (via ANK repeats) (By similarity). Interacts with ZDHHC17 (via ANK repeats).
Belongs to the SNAP-25 family.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > SNARE interactions in vesicular transport.
· Organismal Systems > Immune system > Platelet activation. (View pathway)
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