BCKDHA Antibody - #AF6826
| 製品: | BCKDHA Antibody |
| カタログ: | AF6826 |
| タンパク質の説明: | Rabbit polyclonal antibody to BCKDHA |
| アプリケーション: | ELISA(peptide) |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 50kDa; 50kD(Calculated). |
| ユニプロット: | P12694 |
| RRID: | AB_2847549 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF6826, RRID:AB_2847549.
折りたたみ／展開
;Branched chain alpha keto acid dehydrogenase E1 component alpha polypeptide; FLJ45695; OVD1A; 2 oxoisovalerate dehydrogenase (lipoamide); 2 oxoisovalerate dehydrogenase subunit alpha, mitochondrial; 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; BCKDE1A; BCKDH E1 alpha; BCKDH E1-alpha; BCKDHA; Branched chain alpha keto acid dehydrogenase E1 component alpha chain; Branched chain keto acid dehydrogenase E1 alpha polypeptide; Branched chain keto acid dehydrogenase E1, alpha polypeptide (maple syrup urine disease); Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; MSU; MSUD1; ODBA_HUMAN;
免疫原
A synthesized peptide derived from human BCKDHA.
- P12694 ODBA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAVAIAAARVWRLNRGLSQAALLLLRQPGARGLARSHPPRQQQQFSSLDDKPQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEKVLKLYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNTDLVFGQYREAGVLMYRDYPLELFMAQCYGNISDLGKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYLLSQGWWDEEQEKAWRKQSRRKVMEAFEQAERKPKPNPNLLFSDVYQEMPAQLRKQQESLARHLQTYGEHYPLDHFDK
PTMs - P12694 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S46 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| Y106 | Phosphorylation | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| T114 | Phosphorylation | Uniprot | |
| R117 | Methylation | Uniprot | |
| S206 | Phosphorylation | Uniprot | |
| S207 | Phosphorylation | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| S295 | Phosphorylation | Uniprot | |
| Y307 | Phosphorylation | Uniprot | |
| K311 | Ubiquitination | Uniprot | |
| S337 | Phosphorylation | O14874 (BCKDK) | Uniprot |
| T338 | Phosphorylation | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| S342 | Phosphorylation | Uniprot | |
| S343 | Phosphorylation | Uniprot | |
| Y345 | Phosphorylation | Uniprot | |
| S347 | Phosphorylation | Uniprot | |
| Y353 | Phosphorylation | Uniprot | |
| K356 | Ubiquitination | Uniprot | |
| K445 | Acetylation | Uniprot |
研究背景
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
Mitochondrion matrix.
Heterotetramer of alpha and beta chains.
Belongs to the BCKDHA family.
研究領域
· Metabolism > Amino acid metabolism > Valine, leucine and isoleucine degradation.
· Metabolism > Carbohydrate metabolism > Propanoate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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