5 Lipoxygenase Antibody - #AF6837
| 製品: | 5 Lipoxygenase Antibody |
| カタログ: | AF6837 |
| タンパク質の説明: | Rabbit polyclonal antibody to 5 Lipoxygenase |
| アプリケーション: | ELISA(peptide) |
| 反応性: | Human |
| 分子量: | 80kD; 78kD(Calculated). |
| ユニプロット: | P09917 |
| RRID: | AB_2847560 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF6837, RRID:AB_2847560.
折りたたみ／展開
5 Lipoxygenase; 5 LO; 5 LOX; 5-lipoxygenase; 5-LO; 5-LOX; 5LOX; 5LPG; ALOX 5; Alox5; Arachidonate 5 lipoxygenase; Arachidonate 5-lipoxygenase; arachidonic 5-lipoxygenase alpha-10 isoform; arachidonic 5-lipoxygenase delta-10-13 isoform; arachidonic 5-lipoxygenase delta-13 isoform; arachidonic 5-lipoxygenase delta-p10 isoform; Arachidonic acid 5 lipoxygenase; Leukotriene A4 synthase; LOG 5; LOG5; LOX5_HUMAN; MGC163204;
免疫原
A synthesized peptide derived from human 5 Lipoxygenase.
- P09917 LOX5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI
PTMs - P09917 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y21 | Phosphorylation | Uniprot | |
| Y23 | Phosphorylation | Uniprot | |
| Y43 | Phosphorylation | Uniprot | |
| Y54 | Phosphorylation | Uniprot | |
| Y75 | Phosphorylation | Uniprot | |
| T87 | Phosphorylation | Uniprot | |
| Y95 | Phosphorylation | Uniprot | |
| Y101 | Phosphorylation | Uniprot | |
| T105 | Phosphorylation | Uniprot | |
| Y182 | Phosphorylation | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| T250 | Phosphorylation | Uniprot | |
| T259 | Phosphorylation | Uniprot | |
| T260 | Phosphorylation | Uniprot | |
| S266 | Phosphorylation | Uniprot | |
| S272 | Phosphorylation | Q9UQM7 (CAMK2A) , P17612 (PRKACA) , P49137 (MAPKAPK2) | Uniprot |
| T445 | Phosphorylation | Uniprot | |
| Y446 | Phosphorylation | Uniprot | |
| S448 | Phosphorylation | Uniprot | |
| T486 | Phosphorylation | Uniprot | |
| S523 | Phosphorylation | Uniprot | |
| S524 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| K528 | Acetylation | Uniprot | |
| S532 | Phosphorylation | Uniprot | |
| S664 | Phosphorylation | P28482 (MAPK1) , P27361 (MAPK3) | Uniprot |
| S671 | Phosphorylation | Uniprot |
研究背景
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus.
Cytoplasm. Nucleus matrix. Nucleus membrane>Peripheral membrane protein.
Note: Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.
Interacts with ALOX5AP and LTC4S. Interacts with COTL1, the interaction is required for stability and efficient catalytic activity.
Belongs to the lipoxygenase family.
研究領域
· Human Diseases > Infectious diseases: Parasitic > Toxoplasmosis.
· Metabolism > Lipid metabolism > Arachidonic acid metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Immune system > Fc epsilon RI signaling pathway. (View pathway)
· Organismal Systems > Nervous system > Serotonergic synapse.
· Organismal Systems > Endocrine system > Ovarian steroidogenesis.
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