IRF5 Antibody - #AF6907
| 製品: | IRF5 Antibody |
| カタログ: | AF6907 |
| タンパク質の説明: | Rabbit polyclonal antibody to IRF5 |
| アプリケーション: | ELISA(peptide) |
| 反応性: | Human |
| 分子量: | 55kD,60kD; 56kD(Calculated). |
| ユニプロット: | Q13568 |
| RRID: | AB_2847630 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF6907, RRID:AB_2847630.
折りたたみ／展開
Interferon regulatory factor 5; Interferon regulatory factor 5 bone marrow variant; IRF 5; IRF-5; Irf5; IRF5_HUMAN; SLEB10;
免疫原
A synthesized peptide derived from human IRF5.
- Q13568 IRF5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNQSIPVAPTPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSFGAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRELLSEVLEPGPLPASLPPAGEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKPREKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAGLGVGQGPWPMHPAGMQ
PTMs - Q13568 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T10 | Phosphorylation | Uniprot | |
| Y136 | Phosphorylation | Uniprot | |
| S158 | Phosphorylation | Q9UHD2 (TBK1) | Uniprot |
| S293 | Phosphorylation | Q9UHD2 (TBK1) | Uniprot |
| S301 | Phosphorylation | Uniprot | |
| K309 | Ubiquitination | Uniprot | |
| Y313 | Phosphorylation | Uniprot | |
| Y335 | Phosphorylation | Uniprot | |
| K411 | Ubiquitination | Uniprot | |
| K412 | Ubiquitination | Uniprot | |
| S435 | Phosphorylation | O43353 (RIPK2) | Uniprot |
| S437 | Phosphorylation | Uniprot | |
| S440 | Phosphorylation | Uniprot | |
| S446 | Phosphorylation | O14920 (IKBKB) , O43353 (RIPK2) | Uniprot |
研究背景
Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.
Phosphorylation of serine and threonine residues in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/p300 and initiation of transcription.
'Lys-63'-linked polyubiquitination by TRAF6 is required for activation.
Cytoplasm. Nucleus.
Note: Shuttles between the nucleus and the cytoplasm.
Homodimer, when phosphorylated.
Belongs to the IRF family.
研究領域
· Organismal Systems > Immune system > Toll-like receptor signaling pathway. (View pathway)
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