Phospho-C/EBP epsilon (Thr74) Antibody - #AF3951
| 製品: | Phospho-C/EBP epsilon (Thr74) Antibody |
| カタログ: | AF3951 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-C/EBP epsilon (Thr74) |
| アプリケーション: | ELISA(peptide) |
| 反応性: | Human |
| 分子量: | 31kD(Calculated). |
| ユニプロット: | Q15744 |
| RRID: | AB_2847674 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF3951, RRID:AB_2847674.
折りたたみ／展開
C/EBP epsilon; CCAAT/enhancer binding protein (C/EBP) epsilon; CCAAT/enhancer binding protein epsilon; CCAAT/enhancer-binding protein epsilon; CEBPE; CEBPE_HUMAN; CRP 1; CRP1;
免疫原
A synthesized peptide derived from human C/EBP epsilon around the phosphorylation site of Thr74.
- Q15744 CEBPE_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSHGTYYECEPRGGQQPLEFSGGRAGPGELGDMCEHEASIDLSAYIESGEEQLLSDLFAVKPAPEARGLKGPGTPAFPHYLPPDPRPFAYPPHTFGPDRKALGPGIYSSPGSYDPRAVAVKEEPRGPEGSRAASRGSYNPLQYQVAHCGQTAMHLPPTLAAPGQPLRVLKAPLATAAPPCSPLLKAPSPAGPLHKGKKAVNKDSLEYRLRRERNNIAVRKSRDKAKRRILETQQKVLEYMAENERLRSRVEQLTQELDTLRNLFRQIPEAANLIKGVGGCS
PTMs - Q15744 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T74 | Phosphorylation | Uniprot | |
| Y80 | Phosphorylation | Uniprot | |
| Y107 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| S109 | Phosphorylation | Uniprot | |
| K121 | Acetylation | Uniprot | |
| K121 | Sumoylation | Uniprot | |
| S181 | Phosphorylation | Uniprot | |
| S188 | Phosphorylation | Uniprot | |
| K198 | Acetylation | Uniprot | |
| Y207 | Phosphorylation | Uniprot |
研究背景
Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation.
Phosphorylated.
Nucleus.
Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines.
Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPA, CEBPB and CEBPD (By similarity). Interacts with GATA1 AND SPI1. Interacts with SMARCD2.
Belongs to the bZIP family. C/EBP subfamily.
研究領域
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
· Human Diseases > Cancers: Specific types > Acute myeloid leukemia. (View pathway)
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