Phospho-HRH1 (Ser398) Antibody - #AF3953
| 製品: | Phospho-HRH1 (Ser398) Antibody |
| カタログ: | AF3953 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-HRH1 (Ser398) |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 56kD(Calculated). |
| ユニプロット: | P35367 |
| RRID: | AB_2847676 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF3953, RRID:AB_2847676.
折りたたみ／展開
BPHS, mouse, homolog of; H1 R; H1R; HH1R; HisH1; Histamine H(1) receptor; Histamine H1 receptor; Histamine receptor H1; Histamine receptor subclass H1; Hrh1; HRH1_HUMAN;
免疫原
A synthesized peptide derived from human HRH1 around the phosphorylation site of Ser398.
- P35367 HRH1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
PTMs - P35367 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S68 | Phosphorylation | Uniprot | |
| S70 | Phosphorylation | Uniprot | |
| T140 | Phosphorylation | Q9UQM7 (CAMK2A) | Uniprot |
| T142 | Phosphorylation | Q9UQM7 (CAMK2A) | Uniprot |
| S230 | Phosphorylation | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| K238 | Ubiquitination | Uniprot | |
| S255 | Phosphorylation | Uniprot | |
| K261 | Ubiquitination | Uniprot | |
| S271 | Phosphorylation | Uniprot | |
| S275 | Phosphorylation | Uniprot | |
| T279 | Phosphorylation | Uniprot | |
| K284 | Ubiquitination | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| Y301 | Phosphorylation | Uniprot | |
| Y321 | Phosphorylation | Uniprot | |
| S378 | Phosphorylation | Uniprot | |
| S380 | Phosphorylation | Uniprot | |
| Y386 | Phosphorylation | Uniprot | |
| S396 | Phosphorylation | Q9UQM7 (CAMK2A) , P17612 (PRKACA) , Q13976 (PRKG1) , P17252 (PRKCA) | Uniprot |
| S398 | Phosphorylation | Q13976 (PRKG1) , P17252 (PRKCA) , Q9UQM7 (CAMK2A) , P25098 (GRK2) , P17612 (PRKACA) | Uniprot |
| Y401 | Phosphorylation | Uniprot | |
| T478 | Phosphorylation | P17252 (PRKCA) | Uniprot |
研究背景
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor downregulation.
Cell membrane>Multi-pass membrane protein.
Belongs to the G-protein coupled receptor 1 family.
研究領域
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Organismal Systems > Sensory system > Inflammatory mediator regulation of TRP channels. (View pathway)
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.