APLP2 Antibody - #AF6971
| 製品: | APLP2 Antibody |
| カタログ: | AF6971 |
| タンパク質の説明: | Rabbit polyclonal antibody to APLP2 |
| アプリケーション: | ELISA(peptide) |
| 反応性: | Human |
| 分子量: | 87kD(Calculated). |
| ユニプロット: | Q06481 |
| RRID: | AB_2847761 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF6971, RRID:AB_2847761.
折りたたみ／展開
amyloid beta (A4) precursor like protein 2; Amyloid like protein 2; Amyloid precursor protein homolog HSD 2; amyloid precursor protein homolog HSD2; Amyloid protein homolog; Amyloid-like protein 2; APLP-2; Aplp2; APLP2_HUMAN; APPH; APPL2; CDEBP; CDEI box binding protein; CDEI box-binding protein;
免疫原
A synthesized peptide derived from human APLP2.
Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.
- Q06481 APLP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
PTMs - Q06481 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K78 | Ubiquitination | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| S213 | Phosphorylation | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| Y233 | Phosphorylation | Uniprot | |
| T303 | Phosphorylation | Uniprot | |
| Y327 | Phosphorylation | Uniprot | |
| T367 | O-Glycosylation | Uniprot | |
| T371 | O-Glycosylation | Uniprot | |
| T380 | O-Glycosylation | Uniprot | |
| S381 | O-Glycosylation | Uniprot | |
| K420 | Ubiquitination | Uniprot | |
| R467 | Methylation | Uniprot | |
| S590 | Phosphorylation | Uniprot | |
| T658 | O-Glycosylation | Uniprot | |
| T723 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| T736 | Phosphorylation | P53779 (MAPK10) , P45983 (MAPK8) , P06493 (CDK1) , P45984 (MAPK9) | Uniprot |
| K744 | Ubiquitination | Uniprot | |
| Y750 | Phosphorylation | Uniprot | |
| T754 | Phosphorylation | Uniprot | |
| Y755 | Phosphorylation | Uniprot | |
| K756 | Ubiquitination | Uniprot | |
| Y757 | Phosphorylation | Uniprot |
研究背景
May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).
The BPTI/Kunitz inhibitor domain is O-glycosylated.
Cell membrane>Single-pass type I membrane protein. Nucleus.
Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.
Interacts with CPEB1. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (By similarity).
Belongs to the APP family.
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