CacyBP Antibody - #AF0017

製品: CacyBP Antibody
カタログ: AF0017
タンパク質の説明: Rabbit polyclonal antibody to CacyBP
アプリケーション: WB
反応性: Human
分子量: 26kD(Calculated).
ユニプロット: Q9HB71

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Polyclonal
特異性:
CacyBP Antibody detects endogenous levels of total CacyBP.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

CacyBP;Calcyclin binding protein;Calcyclin-binding protein;CYBP_HUMAN;GIG 5;GIG5;Growth inhibiting gene 5;Growth inhibiting gene 5 protein;hCacyBP;MGC87971;PNAS 107;PNAS107;RP1 102G20.6;S100A6 binding protein;S100A6-binding protein;S100A6BP;Siah-interacting protein;SIP;

免疫原

免疫原:

A synthesized peptide derived from human CacyBP.

Uniprot:

Q9HB71(CYBP_HUMAN) >>Visit HPA database.

タンパク質配列:
MASEELQKDLEEVKVLLEKATRKRVRDALTAEKSKIETEIKNKMQQKSQKKAELLDNEKPAAVVAPITTGYTVKISNYGWDQSDKFVKIYITLTGVHQVPTENVQVHFTERSFDLLVKNLNGKSYSMIVNNLLKPISVEGSSKKVKTDTVLILCRKKVENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAKGDTEF

研究背景

機能:

May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).

PTMs:

Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.

細胞の位置付け:

Nucleus. Cytoplasm.
Note: Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Homodimer. Interacts with proteins of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner (By similarity). Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1.

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