FUNDC1 Antibody - #DF13765
| 製品: | FUNDC1 Antibody |
| カタログ: | DF13765 |
| タンパク質の説明: | Rabbit polyclonal antibody to FUNDC1 |
| アプリケーション: | ELISA(peptide) |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 17kD; 17kD(Calculated). |
| ユニプロット: | Q8IVP5 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
FUN14 domain containing 1; FUN14 domain containing protein 1; FUN14 domain-containing protein 1; FUND1_HUMAN; fundc1;
免疫原
A synthesized peptide derived from Human FUNDC1.
- Q8IVP5 FUND1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATRNPPPQDYESDDDSYEVLDLTEYARRHQWWNRVFGHSSGPMVEKYSVATQIVMGGVTGWCAGFLFQKVGKLAATAVGGGFLLLQIASHSGYVQIDWKRVEKDVNKAKRQIKKRANKAAPEINNLIEEATEFIKQNIVISSGFVGGFLLGLAS
PTMs - Q8IVP5 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y11 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| Y18 | Phosphorylation | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| S41 | Phosphorylation | Uniprot | |
| K119 | Ubiquitination | Uniprot |
研究背景
Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
Phosphorylation at Tyr-18 by SRC inhibits activation of mitophagy. Following hypoxia, dephosphorylated at Tyr-18, leading to interaction with MAP1 LC3 family proteins and triggering mitophagy.
Mitochondrion outer membrane>Multi-pass membrane protein.
Widely expressed.
Interacts (via YXXL motif) with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP.
The YXXL motif mediates the interaction with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP.
Belongs to the FUN14 family.
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