VDAC3 Antibody - #DF13768
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
hVDAC3; mVDAC3; Outer mitochondrial membrane protein porin 3; voltage dependent anion channel 3;
免疫原
A synthesized peptide derived from Human VDAC3.
- Q9Y277 VDAC3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MCNTPTYCDLGKAAKDVFNKGYGFGMVKIDLKTKSCSGVEFSTSGHAYTDTGKASGNLETKYKVCNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTIFVPNTGKKSGKLKASYKRDCFSVGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLSQNNFALGYKAADFQLHTHVNDGTEFGGSIYQKVNEKIETSINLAWTAGSNNTRFGIAAKYMLDCRTSLSAKVNNASLIGLGYTQTLRPGVKLTLSALIDGKNFSAGGHKVGLGFELEA
PTMs - Q9Y277 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Ubiquitination | Uniprot | ||
| C2 | Acetylation | Uniprot | |
| T4 | Phosphorylation | Uniprot | |
| T6 | Phosphorylation | Uniprot | |
| Y7 | Phosphorylation | Uniprot | |
| K12 | Acetylation | Uniprot | |
| K12 | Ubiquitination | Uniprot | |
| K15 | Acetylation | Uniprot | |
| K15 | Ubiquitination | Uniprot | |
| K20 | Acetylation | Uniprot | |
| K20 | Ubiquitination | Uniprot | |
| Y22 | Phosphorylation | Uniprot | |
| K28 | Acetylation | Uniprot | |
| K28 | Ubiquitination | Uniprot | |
| C36 | S-Nitrosylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| Y48 | Phosphorylation | Uniprot | |
| T49 | Phosphorylation | Uniprot | |
| K53 | Ubiquitination | Uniprot | |
| K61 | Acetylation | Uniprot | |
| K61 | Ubiquitination | Uniprot | |
| K63 | Acetylation | Uniprot | |
| K63 | Ubiquitination | Uniprot | |
| C65 | S-Nitrosylation | Uniprot | |
| Y67 | Phosphorylation | Uniprot | |
| T70 | Phosphorylation | Uniprot | |
| K90 | Acetylation | Uniprot | |
| K90 | Ubiquitination | Uniprot | |
| K96 | Acetylation | Uniprot | |
| T107 | Phosphorylation | Uniprot | |
| K109 | Acetylation | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| K110 | Acetylation | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| K113 | Acetylation | Uniprot | |
| K115 | Acetylation | Uniprot | |
| K119 | Acetylation | Uniprot | |
| K163 | Acetylation | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| Y173 | Phosphorylation | Uniprot | |
| K174 | Acetylation | Uniprot | |
| Y195 | Phosphorylation | Uniprot | |
| K197 | Ubiquitination | Uniprot | |
| K224 | Acetylation | Uniprot | |
| Y247 | Phosphorylation | Uniprot | |
| T250 | Phosphorylation | Uniprot | |
| S260 | Phosphorylation | Uniprot | |
| K266 | Acetylation | Uniprot | |
| K266 | Ubiquitination | Uniprot | |
| K274 | Ubiquitination | Uniprot |
研究背景
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
Mitochondrion outer membrane.
Widely expressed. Highest in testis.
Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.
Belongs to the eukaryotic mitochondrial porin family.
研究領域
· Cellular Processes > Cell growth and death > Ferroptosis. (View pathway)
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Human Diseases > Neurodegenerative diseases > Parkinson's disease.
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Human Diseases > Infectious diseases: Viral > Hepatitis B.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Human Diseases > Cancers: Overview > Viral carcinogenesis.
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
· Organismal Systems > Digestive system > Cholesterol metabolism.
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