PPM1D Antibody - #DF13783
| 製品: | PPM1D Antibody |
| カタログ: | DF13783 |
| タンパク質の説明: | Rabbit polyclonal antibody to PPM1D |
| アプリケーション: | ELISA(peptide) |
| 反応性: | Human, Mouse |
| 分子量: | 70kD; 67kD(Calculated). |
| ユニプロット: | O15297 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
EC 3.1.3.16; p53 induced protein phosphatase 1; p53-induced protein phosphatase 1; PP2C delta; PP2C-delta; PP2CD; Ppm1d; PPM1D_HUMAN; Protein phosphatase 1D; protein phosphatase 1D magnesium-dependent delta isoform; Protein phosphatase 2C delta isoform; Protein phosphatase 2C isoform delta; Protein phosphatase magnesium dependent 1 delta; Protein phosphatase magnesium-dependent 1 delta; Protein phosphatase Mg2+/Mn2+ dependent 1D; Protein phosphatase Wip1; Wild type p53 induced phosphatase 1; WIP 1; WIP1;
免疫原
A synthesized peptide derived from Human PPM1D.
Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.
- O15297 PPM1D_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKSLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRKTVCVC
研究背景
Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity).
Nucleus. Cytoplasm>Cytosol.
Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.
Interacts with CHEK1 and CHEK2; dephosphorylates them. Interacts with MAPK14.
Belongs to the PP2C family.
研究領域
· Cellular Processes > Cell growth and death > p53 signaling pathway. (View pathway)
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