製品: PAPD4 Antibody
カタログ: DF13865
タンパク質の説明: Rabbit polyclonal antibody to PAPD4
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
分子量: 50~60kD; 56kD(Calculated).
ユニプロット: Q6PIY7

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
PAPD4 Antibody detects endogenous levels of total PAPD4.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

8030446C20Rik; AI649009; FLJ38499; GLD 2; Gld2; GLD2_HUMAN; hGLD 2; hGLD-2; MGC93684; PAD 4; PAP associated domain containing 4; PAP-associated domain-containing protein 4; papd4; Poly(A) RNA polymerase GLD2; Terminal uridylyltransferase 2; TUTase 2;

免疫原

免疫原:

A synthesized peptide derived from Human PAPD4.

Uniprot:
遺伝子(ID):
発現特異性:
Q6PIY7 GLD2_HUMAN:

Expressed in brain. Within brain, it is expressed in cerebellum, hippocampus and medulla.

タンパク質配列:
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKRQRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELCRTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFRDKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPESFSPAIQLHLVHQAPCNVPPYLSKNESNLGDLLLGFLKYYATEFDWNSQMISVREAKAIPRPDGIEWRNKYICVEEPFDGTNTARAVHEKQKFDMIKDQFLKSWHRLKNKRDLNSILPVRAAVLKR

研究背景

機能:

Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation. Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs.

細胞の位置付け:

Cytoplasm. Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in brain. Within brain, it is expressed in cerebellum, hippocampus and medulla.

サブユニット構造:

Interacts with CPEB1, CPEB2, CPSF1 and PABPC1.

タンパク質ファミリー:

Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.

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