CRB3 Antibody - #DF13932

(2)  
製品: CRB3 Antibody
カタログ: DF13932
タンパク質の説明: Rabbit polyclonal antibody to CRB3
アプリケーション: IHC IF/ICC
反応性: Human, Mouse
分子量: 13~30kD; 13kD(Calculated).
ユニプロット: Q9BUF7

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関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
クローナリティ:
Polyclonal
特異性:
CRB3 Antibody detects endogenous levels of total CRB3.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

CRB3; CRUM3_HUMAN; crumbs homolog 3 (Drosophila); Crumbs protein homolog 3; crumbs, Drosophila, homolog of, 3; PRO1158; protein crumbs homolog 3; UNQ588;

免疫原

免疫原:

A synthesized peptide derived from Human CRB3.

Uniprot:

Q9BUF7(CRUM3_HUMAN) >>Visit HPA database.

遺伝子(ID):
CRB3(92359)
発現特異性:
Q9BUF7 CRUM3_HUMAN:

Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate.

タンパク質配列:
MANPGLGLLLALGLPFLLARWGRAWGQIQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVGLALLVRKLREKRQTEGTYRPSSEEQVGARVPPTPNLKLPPEERLI

研究背景

機能:

Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions.

細胞の位置付け:

Apical cell membrane>Single-pass type I membrane protein. Cell junction>Tight junction.
Note: Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate.

サブユニット構造:

Interacts with MPP5, PARD6A and PATJ.

タンパク質ファミリー:

The PDZ-binding motif is involved in the interactions with PARD6A and MPP5.

研究領域

· Cellular Processes > Cellular community - eukaryotes > Tight junction.   (View pathway)

· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.

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