TGF beta induced factor 2 Antibody - #DF13939

製品: TGF beta induced factor 2 Antibody
カタログ: DF13939
タンパク質の説明: Rabbit polyclonal antibody to TGIF2
アプリケーション: ELISA(peptide)
反応性: Human, Mouse, Rat
分子量: 27kD; 26kD(Calculated).
ユニプロット: Q9GZN2

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
TGF beta induced factor 2 Antibody detects endogenous levels of total TGF beta induced factor 2.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

5' TG 3' interacting factor 2; 5''-TG-3''-interacting factor 2; Homeobox protein TGIF2; TGF (beta) induced transcription factor 2; TGF beta induced factor 2; TGF-beta-induced transcription factor 2; TGFB induced factor 2; TGFB-induced factor 2; Tgif2; TGIF2_HUMAN; Transforming growth factor beta induced factor 2;

免疫原

免疫原:

A synthesized peptide derived from Human TGIF2.

Uniprot:

Q9GZN2(TGIF2_HUMAN) >>Visit HPA database.

遺伝子(ID):
TGIF2(60436)
発現特異性:
Q9GZN2 TGIF2_HUMAN:

Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.

タンパク質配列:
MSDSDLGEDEGLLSLAGKRKRRGNLPKESVKILRDWLYLHRYNAYPSEQEKLSLSGQTNLSVLQICNWFINARRRLLPDMLRKDGKDPNQFTISRRGGKASDVALPRGSSPSVLAVSVPAPTNVLSLSVCSMPLHSGQGEKPAAPFPRGELESPKPLVTPGSTLTLLTRAEAGSPTGGLFNTPPPTPPEQDKEDFSSFQLLVEVALQRAAEMELQKQQDPSLPLLHTPIPLVSENPQ

研究背景

機能:

Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.

PTMs:

The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway.

細胞の位置付け:

Nucleus.
Note: Excluded from nucleoli.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.

サブユニット構造:

Interacts with the transcriptional modulator SMAD3 and the histone deacetylase HDAC1.

タンパク質ファミリー:

Belongs to the TALE/TGIF homeobox family.

研究領域

· Environmental Information Processing > Signal transduction > TGF-beta signaling pathway.   (View pathway)

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